First-Line Maintenance Rucaparib Achieves Longer PFS Vs Placebo Across Subgroups in Newly Diagnosed Ovarian Cancer

September 30, 2022 1:15 pm
by Russ Conroy Results from the phase 3 ATHENA-MONO study suggest that rucaparib could serve as a promising first-line maintenance treatment option in newly diagnosed ovarian cancer. First-line maintenance rucaparib (Rubraca) yielded higher progression-free survival (PFS) compared with placebo among … Read more

Ovarian Cancer Detection Takes a Step Forward

September 12, 2022 1:45 pm
A new type of technology can capture stray ovarian cancer cells from a simple blood test and successfully predict cancer in people who have a lesion or cyst in the pelvic region, according to a new study by a Wilmot … Read more

Study Finds Genetic Counseling for Breast, Ovarian Cancer Syndrome Did Not Significantly Increase with Clinician Support

August 15, 2022 11:11 am
by Erin Hunter Women at high risk for breast and ovarian cancer felt less worried and better informed with educational intervention, even if their attendance of genetic counseling did not significantly increase. A new study shows that access to clinician … Read more

Understanding the genetic testing-related information needs of ovarian cancer patients

July 29, 2022 11:45 am
Reviewed by Emily Henderson, B.Sc. JMIR Publications recently published “Understanding the Information Needs of Patients With Ovarian Cancer Regarding Genetic Testing to Inform Intervention Design: Interview Study” in JMIR Cancer, which reported that experts in gynecological cancer care recommend that … Read more

A Sensor Sniffs for Cancer, Using Artificial Intelligence

May 12, 2022 9:51 am
Biomedical engineer Daniel Heller leads the Cancer Nanomedicine Laboratory at MSK.  Researchers at Memorial Sloan Kettering Cancer Center (MSK) have developed a sensor that can be trained to sniff for cancer, with the help of artificial intelligence. Although the training … Read more

Break Through Cancer Announces $50 Million in Grants to Researchers From Five Top Cancer Research Centers

April 19, 2022 9:13 am
by the ASCO Post Staff Today, 1 year after its founding, Break Through Cancer announced $50 million in grants to support several cutting-edge research projects using a novel “TeamLab” structure—designed to maximize interdisciplinary collaboration among researchers at Dana-Farber Cancer Institute, … Read more

Key to detecting ovarian cancer early may be in the fallopian tubes

April 4, 2022 3:20 pm
by Caren Begun Tennis legend Chris Evert—known for her 18-time grand slam success in the sport—has made recent headlines after revealing an early-stage ovarian cancer diagnosis and speaking out to help others by sharing her personal experience. According to the … Read more

Could Pap smears one day help detect breast and ovarian cancers?

February 1, 2022 5:33 pm
by Angus Chen New research suggests that cervical cancer screenings could be used to pick up on a patient’s risk of breast, ovarian, and endometrial cancers. Routine screenings have become a powerful tool in catching cervical cancer as early … Read more

Small device for earlier ovarian cancer detection

January 19, 2022 8:40 am
by Emily Dieckman Jennifer Barton, director of the University of Arizona BIO5 Institute and Thomas R. Brown Distinguished Chair in Biomedical Engineering, has spent years developing a device small enough to image the fallopian tubes. Credit: Chris Richards/University of Arizona… Read more

BRCA Testing Underused in Women With Ovarian Cancer

January 14, 2022 9:00 am
by M. Alexander Otto, MMS, PA Despite unequivocal recommendations for universal germline BRCA testing in women with ovarian cancer, an analysis of a large commercial insurance database between 2008 and 2018 found that only about one third (33.9%) of such … Read more

Repare Therapeutics’ RP-3500 Shows Potential of ATR Inhibitors in Precision Oncology

November 4, 2021 11:09 am
by Alison Kanski NEW YORK – Pharma companies are racing to develop oral ATR inhibitors that present a unique pan-cancer market opportunity. Researchers reported positive Phase I results on one of these drugs, Repare Therapeutics’ RP3500, last month across tumor … Read more

How ovarian cancers evade the immune system

October 6, 2021 12:00 am
By Krista Conger It’s diabolical, and so clever. Recent research by cancer biologist Wendy Fantl, PhD, and immunologist and cancer biologist Veronica Gonzalez, PhD, shows that ovarian tumors thrive by convincing nearby immune cells that the cancer cells are those … Read more

Symptoms of Ovarian Cancer Explained as Woman Diagnosed Thanks to Small Navel Growth

September 28, 2021 12:00 am
By Aatif Sulleyman A woman is raising awareness of ovarian cancer and how difficult it can be to detect, having been diagnosed with the illness by a dermatologist who removed a small growth from her navel. Despite being aware of … Read more

Finding cancer earlier: New tests show promise with broader screening available

August 19, 2021 9:33 pm
By Meg Tully Rosemary Jemo volunteered for a blood test trial based on pioneering research from Johns Hopkins University because she thought it would be great if it could save lives. The 71-year-old Pennsylvania hairdresser now believes that decision saved … Read more

Old Antibiotic Targets BRCA-Mutated, PARP Inhibitor-Resistant Tumors

June 18, 2021 12:21 pm
Studies in laboratory cell lines and in mouse tumor models show an antibiotic developed in the 1950s called novabiocin effectively targets and kills cancer cells with abnormal BRCA1 or BRCA2 genes, which normally help to repair damaged DNA.… Read more

Universal Genetic Testing Is Far From a Reality in Patients With Ovarian Cancer

June 8, 2021 11:28 am
by Victoria Forster, PhD Rates of genetic testing in ovarian cancer “remain well below the goal of universal testing,” according to authors of a systematic review and meta-analysis published in Gynecologic Oncology.1… Read more

Electronic Olfaction System Under Study as Screening Tool for Pancreatic and Ovarian Cancers

June 5, 2021 9:00 am
An odor-based test that detects vapors emanating from blood samples was able to distinguish between benign and pancreatic and ovarian cancer cells with up to 95% accuracy, according to a new study presented by Johnson et al during the 2021 … Read more

‘Devastated and Sad’ After 36 Years of Research — Early Detection of Ovarian Cancer Doesn’t Save Lives

May 19, 2021 1:00 pm
By Professor Ian Jacobs I was motivated to improve the outcome for women with ovarian cancer by my experience as a junior doctor in London in 1985. But 36 years on, the results aren’t what we’d hoped. My colleages’ and … Read more

Disappointment: Screening for Ovarian Cancer Does Not Cut Deaths

May 13, 2021 12:00 pm
By Pam Harrison Results from a huge British trial that involved more than 200,000 women who were followed for a median of 16 years have turned out negative. Investigators found that annual screening for ovarian cancer with either multimodal screening … Read more

ARIEL2 Analysis Sheds Light on Biomarkers of Response to Rucaparib in Ovarian Cancer

May 4, 2021 2:00 pm
RAD51C and RAD51D mutations and high-level BRCA1 promotor methylation are predictive of response to rucaparib in patients with recurrent ovarian cancer, while genomic scars linked with homologous recombination deficiency is predictive of response only in those with platinum-sensitive disease. By … Read more