Preventing Chemo Brain? Study Identifies Potential Approach for Common Problem

November 2, 2022 4:22 pm

by NCI Staff

A side effect of some cancer treatments commonly referred to as “chemo brain” has received increasing attention from researchers in recent years. Often referred to as cancer-related cognitive impairment, chemo brain can be marked by severe memory … Read more

Immune receptors recognizing mutations in p53 could guide immunotherapies for solid tumors

September 6, 2022 1:48 pm

CCR scientists have identified dozens of naturally occurring receptors that direct immune cells to tumors with mutations in p53, the most commonly mutated gene in human cancers. The research team, led by Steven Rosenberg, M.D., Ph.D., Chief of the … Read more

Vitamin D therapy may be a useful addition to the treatment of ovarian cancer, study suggests

July 26, 2022 12:35 pm

by Emily Henderson, B.Sc.

Ovarian cancer has one of the highest death rates of all cancers. One reason for this is that cancer turns the body’s defenses against itself. However, new research from Nagoya University published in Matrix Biology suggests … Read more

A Sensor Sniffs for Cancer, Using Artificial Intelligence

May 12, 2022 9:51 am

Biomedical engineer Daniel Heller leads the Cancer Nanomedicine Laboratory at MSK. 

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have developed a sensor that can be trained to sniff for cancer, with the help of artificial intelligence.

Although the training … Read more

Novel metabolic mechanisms contribute to how ovarian cancer evades immune attack, research finds

March 16, 2022 9:43 am

by Emily Henderson, B.Sc.

High-grade serous carcinoma is the most aggressive form of ovarian cancer and accounts for the majority of advanced-stage cases. The poor outcomes associated with the disease underscore the need for more effective treatments. A research team … Read more

‘Drug factory’ implants eliminate ovarian, colorectal cancer in mice

March 2, 2022 11:45 am

by Jade Boyd

Rice immunotherapy treatment could begin human clinical trials this year

HOUSTON – (March 2, 2022) – Rice University bioengineers have shown they can eradicate advanced-stage ovarian and colorectal cancer in mice in as little as six days

Read more

Ovarian Cancer Chemotherapy Resistance Linked to Stress-Associated Gene Expression Features

February 23, 2022 9:24 am

NEW YORK – A team led by researchers at the University of Helsinki has uncovered stress-related tumor and microenvironment gene expression features that appear to coincide with chemotherapy resistance and shorter progression-free survival in individuals with high-grade serous ovarian cancer.… Read more

The secret hideouts of ovarian cancer revealed

February 11, 2022 9:53 am

Every year, roughly 550 women develop ovarian cancer in Finland. Ovarian cancer is difficult to treat and it is commonly fatal, with 320 women dying of ovarian cancer annually in Finland.

Cancer can only develop and progress when the tumour … Read more

Small device for earlier ovarian cancer detection

January 19, 2022 8:40 am

by Emily Dieckman

Jennifer Barton, director of the University of Arizona BIO5 Institute and Thomas R. Brown Distinguished Chair in Biomedical Engineering, has spent years developing a device small enough to image the fallopian tubes. Credit: Chris Richards/University of ArizonaRead more

Study Shows How Ovarian Cancer Starts in High-Risk Women

December 28, 2021 10:47 am

by Cedars-Sinai

Findings Hold Potential for Predicting Many Years in Advance Which Women With the BRCA-1 Mutation Will Develop Disease

Newswise — Los Angeles (December 28, 2021). –Ovarian cancer is the leading cause of gynecologic cancer deaths in the U.S., … Read more

MCW scientists uncover potential therapeutic target and biomarker for ovarian cancerPortfolio Inspiration

November 17, 2021 11:28 am

MEDICAL COLLEGE OF WISCONSIN

The study’s findings suggest targeting protein FXR1 to inhibit the progression of the cMYC oncogene, a gene mutation often over-expressed in patients with ovarian cancer

Scientists at the Medical College of Wisconsin (MCW) Cancer Center and … Read more

Ludwig Lausanne team devises a method to selectively grow tumor-targeting T cells for cancer therapy

November 15, 2021 10:02 am

NOVEMBER 15, 2021, NEW YORK – A Ludwig Cancer Research study has devised a highly efficient method to generate large numbers of immune cells specifically engineered to recognize neoantigens—small fragments of randomly mutated proteins that are typically unique to a … Read more

Study Points to New Approach to Improve Ovarian Cancer Treatment

November 12, 2021 9:31 am

By Asher Jones

Immune checkpoint inhibitors are a type of cancer treatment that help the immune system’s T cells recognize and attack tumors. But these immunotherapy drugs aren’t effective against all cancers. In a study published today in Science AdvancesRead more

Ludwig Cancer Research study identifies cellular interactions essential to the immune attack on ovarian tumors

November 5, 2021 4:45 pm

NOVEMBER 5, 2021, NEW YORK – A Ludwig Cancer Research study has uncovered a cellular interaction that is essential to the ability of the immune system’s cytotoxic T lymphocytes to destroy ovarian tumors and shown that its engagement could help … Read more

Yale Cancer Center Study Shows New Strategy to Fight Drug Resistance in HER2-Positive Breast and Ovarian Cancers

October 28, 2021 11:00 am

by Anne Doerr

New findings by researchers at Yale Cancer Center demonstrate a novel strategy to treat tumor growth in breast and ovarian cancers characterized by HER2 gene amplification, an increase in the number of copies of a gene. Gene … Read more

How ovarian cancers evade the immune system

October 6, 2021 12:00 am

By Krista Conger

It’s diabolical, and so clever. Recent research by cancer biologist Wendy Fantl, PhD, and immunologist and cancer biologist Veronica Gonzalez, PhD, shows that ovarian tumors thrive by convincing nearby immune cells that the cancer cells are those … Read more

Cancer Discovery Could Revive Failed Treatments for Solid Tumors

April 5, 2021 11:00 am

New research from the UVA Cancer Center could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials.

The research from UVA’s Jogender Tushir-Singh, PhD, explains why … Read more

Improving Cancer Immunotherapy by Blocking Glucose Supply

February 17, 2021 11:00 am

All cells use sugar as a vital source of energy and building blocks. Unfortunately, that means even cancer cells use sugar. Researchers at Memorial Sloan Kettering (MSK) Cancer Center wondered what happens when tumor cells and immune cells battle for … Read more

Link Between Driver of Ovarian Cancer and Metabolism Opens Up New Therapeutic Strategies

January 11, 2021 3:00 pm

Loss of ARID1A causes increased glutamine metabolism, which can be blocked pharmacologically to target ARID1A-mutant tumors.

Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according … Read more

Elevated Stress Hormone Levels Could Reawaken Dormant Cancer Cells, Study Finds

December 2, 2020 5:00 pm

By Shraddha Chakradhar

The recurrence of cancer months or even years after successful treatment is an all too common phenomenon, and scientists have been chipping away at understanding how undetectable cells can once again unleash disease on the body — … Read more