Immunotherapy With Neoadjuvant Chemotherapy Signals Efficacy in Advanced-Stage Ovarian Cancer

March 19, 2020 11:00 am

By Nichole Tucker

GEN-1 immunotherapy demonstrated dose-dependent efficacy results in newly diagnosed patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (EOC) when treated in combination with the standard of care, according to results from the OVATION 2 … Read more

New Research Shows Which Ovarian Cancer Patients Won’t Benefit From Immune-PARP Combo

March 19, 2020 10:10 am

BOSTON – In patients with advanced ovarian cancer, a combination of drugs known as immune checkpoint inhibitors and PARP inhibitors can produce powerful remissions, clinical trials have shown, but up until now investigators haven’t been able to predict which patients … Read more

Pathogenic Variants in RAD51C and RAD51D Linked to Ovarian and Breast-Cancer Risk

March 7, 2020 10:00 am

By Will Boggs MD

NEW YORK (Reuters Health) – Pathogenic variants in RAD51C and RAD51D are associated with an increased risk of ovarian and breast cancer, researchers report.

“RAD51C and RAD51D are included in cancer gene panels that are widely … Read more

Family History of Heart Disease Makes Premature Removal of Ovaries Especially Risky

March 4, 2020 11:00 am

CLEVELAND, Ohio (March 4, 2020)–Women who proactively have their ovaries removed to minimize their cancer risk may face a greater risk–premature death because of heart disease. That’s according to a new study that identifies an increased risk for women with … Read more

IMV preps pivotal trials for ovarian cancer T cell therapy

February 26, 2020 11:00 am

IMV says new results from its phase 2 trial of lead drug DPX-Survivac, designed to stimulate a T cell response in ovarian cancer, have set it on course for a registration trial.

The Canadian biotech revealed data from the 22-patient … Read more

Research Suggests Statins Could Lower Ovarian Cancer Risk

February 18, 2020 10:00 am

By Cancer Research UK

A genetic study has found evidence to suggest that women who take statins in the long term could be less likely to develop ovarian cancer, according to new research funded by Cancer Research UK published today … Read more

Simple Blood Test Measures the Body’s Immune Response to Improve Ovarian Cancer Diagnosis

February 17, 2020 10:00 am

Researchers have developed a simple blood test that measures the body’s own immune response to improve diagnosis of ovarian cancer.

Ovarian cancer is one of the most common gynecologic cancers, with the highest mortality rate. About 300,000 new cases are … Read more

Ovarian Cancer Symptom: General Discomfort In This Body Part Could Be A Warning Sign

February 16, 2020 10:00 am

By Divya Ramaswamy

Key Points

  • >21,000 American women are diagnosed with ovarian cancer every year
  • Only 19% of ovarian cancers are diagnosed at an early stage
  • General abdominal discomfort could be an early warning sign

With more than 21,000 American … Read more

Higher Risk of Ovarian Clear Cell Cancer in Asian Pacific Islanders

February 14, 2020 10:00 am

By Christina Bennett, MS

Regardless of birthplace, women who are Asian Pacific Islanders may have a higher risk of developing ovarian clear cell cancer compared with other ethnicities, according to a population-based retrospective cohort study. The findings were recently published … Read more

IFN-Activated Monocytes Show Early Promise For Ovarian Cancer

February 13, 2020 11:00 am

By Sharon Worcester

REPORTING FROM THE CLINICAL IMMUNO-ONCOLOGY SYMPOSIUM

– Intraperitoneal infusions of peginterferon alfa-2b and interferon gamma-1b, administered with or without autologous monocytes, showed antitumor activity and tolerability in heavily pretreated patients with ovarian cancer in a first-in-human
Read more

Study Shows “Self-eating” Genes may Act as Tumor Suppressors in Ovarian Cancer

February 13, 2020 10:00 am

By Peter Hofland, Ph.D

Scientists at the Medical University of South Carolina (MUSC) and the University of California at San Diego (UCSD) are shedding light on a decades-old controversy, showing that autophagy or “self-eating” genes work against tumors … Read more

Oncology Massage Therapy Shows Promise for Chemotherapy-Induced Peripheral Neuropathy

February 10, 2020 10:00 am

By Kate O’Rourke

San Francisco—Results from a pilot study evaluating two treatment schedules of a standardized Swedish massage technique to treat chemotherapy-induced peripheral neuropathy (CIPN) showed that both massage two and three times per week could reduce CIPN-related symptoms. The … Read more

Supercharged Cancer Cells Outrun Chemo, Race toward Immunotherapy

February 7, 2020 10:00 am

Cancer cells operate in mutational overdrive, which allows them to blow past chemotherapy and other would-be enforcers of physiological order. Cancer’s speeding, however, may prove to be a vulnerability, say scientists from the Mayo Clinic, the Institute of Cancer Research, … Read more

ASCO Guideline: Germline Testing Recommended for All Women Diagnosed With Epithelial Ovarian Cancer

February 6, 2020 11:00 am

By Susan Moench, PhD, PA-C

A central tenant of a recently issued American Society of Clinical Oncology (ASCO) guideline is that all women with a diagnosis of epithelial ovarian cancer should be offered testing for specific germline mutations associated with … Read more

Psychedelic Mushrooms Can Help Ease Anxiety and Depression in Cancer Patients for Years, Scientists Believe

February 3, 2020 11:00 am

By Kashmira Gander

Taking a single dose of a psychedelic compound found in magic mushrooms can ease symptoms of anxiety and depression in cancer patients for years, according to a study.

Almost five years after taking the compound psilocybin while … Read more

Researchers find cancer-fighting potential in non-cancer drugs

January 28, 2020 11:00 am

By Julie Steenhuysen

(Reuters Health) – U.S. researchers who tested the cancer-fighting properties of more than 4,500 non-cancer drugs found nearly 50 drugs for other conditions showed at least some cancer-killing ability.

“We found that a surprising number of non-oncology … Read more

Tweaking how CAR-T therapy kills tumors could stop a dangerous side effect, study finds

January 28, 2020 10:00 am

By Sharon Begley

As every trauma surgeon knows, there are messy bullet wounds and there are neat ones, and the former cause incomparably more trouble. If a team of scientists in China is right, the same principle may explain why … Read more

Use of intrauterine devices may decrease risk for ovarian cancer

January 24, 2020 10:00 am

About 14,000 women each year die of ovarian cancer, making it one of the deadliest gynecologic cancers.

Moreover, 80% of ovarian cancer diagnoses occur only after the disease has progressed to a late stage. The Ovarian Cancer Research Alliance estimated … Read more

“One-size-fits-all” cancer treatment could be on the horizon after scientists discover new immune cell by accident

January 24, 2020 10:00 am

By Kashmira Gander

Scientists have discovered a new cell in the immune system that can kill many types of cancer, which they hope could one day be used to create a “one size fits all” treatment for the disease.

In … Read more

PALB2 Linked to Increased Risk for Breast, Ovarian, and Pancreatic Cancer

January 8, 2020 10:00 am

By Christina Bennett, MS

Germline PALB2 pathogenic variants were associated with an increased risk for female breast cancer, male breast cancer, ovarian cancer, and pancreatic cancer, and these risks varied by age, according to data from an international study … Read more