Claudia’s Story: Clearity Was My Rock!

November 23, 2020 5:54 pm

Like many women, Claudia knew something wasn’t quite right when she began to experience an unusual pain in her pelvic area and excessive sweating while at work. Later in the night, she ended up in the hospital with emergency surgery, … Read more

New Combination Treatment for Recurrent Ovarian Cancer Shows Positive Outcomes

November 19, 2020 5:00 pm

A team from Roswell Park Comprehensive Cancer Center has detailed striking findings on the effectiveness of a previously untried combination of old and new drugs as treatment for recurrent ovarian cancer.

In a new article in JAMA Oncology, the … Read more

‘Next-Gen’ Immunotherapy Active in Advanced Cancers

November 16, 2020 5:00 pm

Disease control in two-thirds of patients treated with bispecific antibody.

By Charles Bankhead

An investigational drug that combines PD-1/L1 inhibition and T-cell stimulation led to disease control in two-thirds of patients with unresectable advanced solid malignancies, a preliminary clinical study … Read more

Improvements to Cancer Clinical Trials After COVID-19 Wreckage

November 3, 2020 3:00 pm

By Kate Johnson

As the COVID-19 pandemic rolled across North America earlier this year, cancer clinics shut their doors, patients stayed home, and oncology researchers contemplated an unthinkable setback as laboratory closures and trial freezes threatened the demise of years … Read more

SRS Instead of WBRT for Patients With Multiple Brain Metastases

October 29, 2020 3:00 pm

 Roxanne Nelson, RN, BSN

Stereotactic radiosurgery (SRS) should replace whole-brain radiotherapy (WBRT) as the new standard of care for patients with four or more brain metastases, say researchers who report results from a randomized trial conducted in patients with … Read more

The Stressful Conclusion of a Clinical Trial

October 29, 2020 9:00 am

By 

Does a pharmaceutical company have a moral obligation to acknowledge my participation with an ongoing supply of the product that I helped test?

When I learned this summer that the clinical trial of the cancer drug that … Read more

ASCO Advises Against PARP Inhibitor Retreatment in Ovarian Cancer

October 28, 2020 4:00 pm

By Andrew D. Bowser

New guidelines recommend against retreatment with poly (ADP-ribose) polymerase (PARP) inhibitors in women with epithelial ovarian, tubal, or primary peritoneal cancer (EOC). However, trials investigating retreatment are underway, so this recommendation may change.

The guidelines, from … Read more

KSQ Boosts PARP Inhibition In Models Of Cancer With USP1 Inhibitor

October 27, 2020 7:00 pm

KSQ Therapeutics is hoping to provide hope for ovarian and breast cancer patients that have developed a resistance to drugs and those who don’t respond at all by developing a drug that may be able to boost the effectiveness of … Read more

Adagrasib a Promising New Treatment for Lung, Pancreatic, Endometrial, Ovarian and Colon Cancers

October 27, 2020 6:00 pm

By Mary Moore

A new drug that inhibits a cancer mutation in the KRAS gene has shown encouraging results in patients with lung cancer, colon cancer, and other solid tumors.

For decades, scientists have been trying to develop new … Read more

New BRAF Inhibitor Cancer Drug Shows Efficacy

October 26, 2020 4:00 pm

By Robert Dillard

A new drug developed to treat cancers with an altered BRAF gene has shown efficacy in an early patient trial, according to a study presented at the 32nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics, … Read more

Most Cancer Patients Would Join a Clinical Trial if Offered the Chance

October 20, 2020 4:00 pm

By Anne Harding

New findings debunk the conventional wisdom that Black cancer patients are less likely to agree to participate in clinical trials.

Overall, 55% of patients offered trial participation agreed to enroll, and white and Black patients agreed to … Read more

Two-Stage Surgery to Reduce Ovarian Cancer Risk Piques Interest

October 16, 2020 6:00 pm

 Sharon Worcester

“Many physicians would assume that prevention of cancer, especially cancer as serious as ovarian cancer, trumps all other decision making, but when we really listen to high-risk women, they want to have options,” Karen Lu, MD, … Read more

Clearity’s Scientific Director, Dr. Deb Zajchowski, Honored as a 2020 Ovarian Cancer Hero

October 14, 2020 4:02 pm

Clearity’s very own, Dr. Deborah Zajchowski, has been announced as a 2020 Ovarian Cancer Hero!

CURE’s Third Annual Ovarian Cancer Heroes® awards program recognizes individuals for their heroic contributions in the field of ovarian cancer. This year’s annual evening of … Read more

Large Genomics Study Points the Way to Future Cancer Clinical Trials

October 14, 2020 11:00 am

By Angus Liu

Many oncology researchers and practitioners scrutinize genetic alterations in cancer, but they either focus on one particular tumor type or one mutation that occurs across tumors. A large-scale study focusing on precision medicine in cancer is now … Read more

CURE Media Group Announces the 2020 Ovarian Cancer Heroes® Winners

October 12, 2020 9:30 am

CURE Media Group, the industry-leading multimedia platform devoted to cancer updates and research that reaches over 1 million patients, has named the winners of its Third Annual Ovarian Cancer Heroes® awards program. The virtual celebration will be held Friday, … Read more

Triple therapy Shows Promise in Non-Germline BRCA-Mutated Ovarian Cancer

October 10, 2020 5:00 pm

By Savannah Demko

Triple therapy with olaparib plus durvalumab and bevacizumab were well-tolerated in patients with non-germline BRCA-mutated, platinum-sensitive, relapsed ovarian cancer, according to data presented at ESMO Virtual Congress 2020.

“Preclinical studies suggest the potential for synergy between … Read more

A Common Plant Virus Is an Unlikely Ally in the War on Cancer

October 5, 2020 3:00 pm

Researchers have seen promising results by injecting dog and mouse tumors with the cowpea mosaic virus. Now they’re aiming for a human trial.

By Daniel Oberhaus

Jack Hoopes spends a lot of time with dying dogs. A veterinary radiation specialist
Read more

Bayer’s ATR Inhibitor May Benefit Cancers With ATM Aberrations, Early Data Suggest

September 29, 2020 4:00 pm

Researchers are optimistic that data from a first-in-human clinical trial of Bayer’s ATR-inhibiting agent, BAY-1895344, may pave the way for a new class of precision oncology treatments for patients with certain DNA damage response (DDR) defects in their tumors.

The … Read more

FDA Grants Expanded Access Program to Ulixertinib for MAPK Pathway Aberrant Cancer

September 29, 2020 3:00 pm

By Matthew Fowler

xCures recently announced that the FDA granted its IND immediate Expanded Access Program for the ERK inhibitor ulixertinib to treat patients with MAPK pathway aberrant cancer.

The FDA granted the investigational new drug application for the ERK

Read more

Halting Cancer by Halting DNA Repair

September 25, 2020 11:00 am

By Liam Drew

PARP inhibitors are rapidly transforming the treatment of ovarian, breast, prostate and other types of cancer. To develop these drugs, researchers supported by Cancer Research UK had to decipher how blocking DNA repair could expose a weak … Read more