Claudine Isaacs, MD, on the Limitations of At-Home Genetic Tests for Hereditary Breast/Ovarian Cancers

More than 95% of BRCA1 or BRCA1 pathogenic variants would have been missed by DTC testing, largest such study showed

November 8, 2023 9:00 am

By Mark Fuerst

Direct-to-consumer (DTC) genetic testing has limited use as a screening tool for identifying individuals at risk of hereditary breast or ovarian cancer, especially in those of non-Ashkenazi Jewish descent, researchers reported.

Most current DTC genetic tests evaluate … Read more

First Blood Test for Dozens of Hereditary Cancers Approved by FDA

October 2, 2023 9:00 am

The FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. The Invitae Common Hereditary Cancers Panel evaluates a blood sample to identify DNA variants in 47 genes associated with an elevated risk … Read more

Dr Rebecca Brooks Covers Ovarian Cancer Risk Factors, Preventive Measures

September 29, 2023 9:00 am

By Hayden E. Klein

For Ovarian Cancer Awareness Month in September, Rebecca Brooks, MD, talked to The American Journal of Managed Care® (AJMC®) about how genetics and family history play a large role in ovarian cancer … Read more

Clinical trial gives women with gene mutation power over disease

September 8, 2023 9:00 am

Shared by Norma Rabago

When Juana Padron, a 40-year-old mother of four, chose to have a genetic test, going against her friends and family’s advice was the last thing on her mind.

Padron’s aunt died from breast cancer, and she … Read more

Fred Hutch study highlights racial disparities in ovarian cancer risk for women

May 4, 2023 2:48 pm

Researchers examined risks for Black and white women with endometriosis and fibroids to understand how common medical interventions for those conditions modified the outcomes

SEATTLE, WA — May 4, 2023 — A new Fred Hutchinson Cancer Center study in the

Read more

Exome sequencing identifies cancer predisposition-gene carriers screening guidelines miss

April 19, 2023 12:55 pm

by Jennifer Southall

Whole-exome sequencing identified carriers of predisposition genes for hereditary breast and ovarian cancer or Lynch syndrome who, under current guidelines, would not have qualified for genetic testing, according to study results.

The findings, presented at American Association … Read more

Tailored Phone Calls Increased Rate of Genetic Testing, Counseling for Hereditary Cancer Risk

March 2, 2023 9:44 am

by Alison Kanski

NEW YORK – Personalized phone discussions about genetic risk assessment increased the number of breast and ovarian cancer patients who got genetic testing or discussed their risk with a genetic counselor, a study from Rutgers Cancer Institute … Read more

Ovarian Cancer in Black and African American Communities

February 3, 2023 3:10 pm

Ovarian cancer outcomes are less positive for Black and African American persons compared to other communities, but the reasons why are not entirely clear. Anne Mette Buhl, PhD, Director of Science and Clinical Trials, from The Clearity Foundation, recently contributed Read more

OCRA Issues Consensus Statement Calling for Consideration of Fallopian Tube Removal to Prevent Ovarian Cancer

February 3, 2023 2:16 pm

by Jo Cavallo

The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) has shown that general population screening did not significantly reduce ovarian and tubal cancer deaths, and the researchers concluded that such screening cannot be recommended. The findings from … Read more

Ovarian cancer surveillance results in earlier diagnosis for women with faulty BRCA genes who want to defer surgery

November 1, 2022 4:17 pm

by British Medical Journal

Regularly monitoring women with faulty BRCA genes that make them highly susceptible to ovarian cancer results in earlier stage diagnosis in those who want to defer preventive surgery, finds research published online in the Journal of Read more

Melissa Frey, MD, on Disparities in Ovarian Cancer Genetic Testing

October 19, 2022 10:40 am

by Mark L. Fuerst

Most people with a hereditary ovarian cancer syndrome are unaware of their underlying mutation, and the majority have not had genetic testing.

In a recent article in the ASCO Educational Book, Melissa Frey, MD, MS, … Read more

Identifying the Underlying Causes of Ovarian Cancer

October 6, 2022 1:48 pm

by Cedars-Sinai

New Studies Led by Cedars-Sinai Investigators Help Pinpoint Genetic Risk Factors Tied to Increased Risk of Ovarian Cancer and Suggest How to Better Identify Women Most At Risk

Image on left: Simon Gayther, PhD, professor of Biomedical Sciences, Read more

Nonselective Beta-Blockers May Improve Outcomes in Ovarian Cancer

August 29, 2022 2:19 pm

by Charles Bankhead

Women with cardiovascular conditions (CVCs) and ovarian cancer had better 2-year survival if they received a nonselective beta blocker (NSBB) at or around the time of cancer surgery, a review of medical records showed.

Two-year postoperative survival … Read more

Study Finds Genetic Counseling for Breast, Ovarian Cancer Syndrome Did Not Significantly Increase with Clinician Support

August 15, 2022 11:11 am

by Erin Hunter

Women at high risk for breast and ovarian cancer felt less worried and better informed with educational intervention, even if their attendance of genetic counseling did not significantly increase.

A new study shows that access to clinician

Read more

Meta-Analysis Examines Link Between Aspirin Use and Ovarian Cancer Risk

July 28, 2022 10:32 am

by The ASCO Post Staff

Frequent aspirin use may be linked with lower ovarian cancer risk in individuals with multiple risk factors, according to a new study published by Hurwitz et al in the Journal of Clinical Oncology.

“Ovarian … Read more

Key to detecting ovarian cancer early may be in the fallopian tubes

April 4, 2022 3:20 pm

by Caren Begun

Tennis legend Chris Evert—known for her 18-time grand slam success in the sport—has made recent headlines after revealing an early-stage ovarian cancer diagnosis and speaking out to help others by sharing her personal experience.

According to the … Read more

Oral Contraceptive Pills Protect Against Ovarian and Endometrial Cancer, Study Finds

December 18, 2020 11:00 am

A study has shown that the use of oral contraceptives gave women a much lower risk of developing both ovarian and endometrial cancer.

A study involving more than 250,000 women has shown that the use of oral contraceptives can protect … Read more

SRS Instead of WBRT for Patients With Multiple Brain Metastases

October 29, 2020 3:00 pm

 Roxanne Nelson, RN, BSN

Stereotactic radiosurgery (SRS) should replace whole-brain radiotherapy (WBRT) as the new standard of care for patients with four or more brain metastases, say researchers who report results from a randomized trial conducted in patients with … Read more

Two-Stage Surgery to Reduce Ovarian Cancer Risk Piques Interest

October 16, 2020 6:00 pm

 Sharon Worcester

“Many physicians would assume that prevention of cancer, especially cancer as serious as ovarian cancer, trumps all other decision making, but when we really listen to high-risk women, they want to have options,” Karen Lu, MD, … Read more

Universal BRCA Testing Could Prevent Countless Cancer Deaths

July 17, 2020 1:00 pm

By Diana Swift

Population screening found to be cost-effective for higher income countries

Screening entire populations of women for mutations in breast and ovarian cancer susceptibility genes could prevent hundreds of thousands of cases in the U.S., and millions globally, … Read more