BRCA Testing Underused in Women With Ovarian Cancer

January 14, 2022 9:00 am

by M. Alexander Otto, MMS, PA

Despite unequivocal recommendations for universal germline BRCA testing in women with ovarian cancer, an analysis of a large commercial insurance database between 2008 and 2018 found that only about one third (33.9%) of such … Read more

Why Black women with ovarian cancer require greater focus

December 15, 2021 9:55 am

by Sophia George

Providing equal access to care will not by itself equalize outcomes between Black and white women.

Women from the African diaspora are disproportionately affected by high-grade and aggressive ovarian tumours. In the United States, mortality due to … Read more

MSK Fellows Develop Online Resource to Increase Awareness of Genetic Cascade Testing

October 21, 2021 12:00 am

by Alison Kanski

NEW YORK – Gynecologic oncology fellows at Memorial Sloan Kettering have developed an online resource for cancer patients, family members, and doctors aiming to raise awareness of genetic cancer risks and spur more testing among relatives for … Read more

Women with genetic mutations fare no worse with breast or ovarian cancer, study finds

October 1, 2021 12:00 am

By Krista Conger

Newly diagnosed breast or ovarian cancer patients who carry common cancer-associated mutations have similar or better short-term survival rates than those with no mutations, researchers report.

Women newly diagnosed with breast or ovarian cancer who are also … Read more

Universal Genetic Testing Is Far From a Reality in Patients With Ovarian Cancer

June 8, 2021 11:28 am

by Victoria Forster, PhD

Rates of genetic testing in ovarian cancer “remain well below the goal of universal testing,” according to authors of a systematic review and meta-analysis published in Gynecologic Oncology.1Read more

Most Patients With Breast, Ovarian Cancer Patients Do Not Undergo Genetic Testing

March 1, 2021 7:00 pm

By Christina Bennett, MS

The number of genes tested for ovarian and breast cancer has grown in recent years, but most patients do not undergo testing.  Thus, variant-of-unknown-significance (VUS) results are common, especially among minority populations, according to the results … Read more

How Biomarker Testing May Help Women Battling Ovarian Cancer

February 18, 2021 6:00 pm

Receiving a cancer diagnosis can be overwhelming. But the more you know about your specific situation, the better.

By

Every year, more than 21,000 women in the United States are diagnosed with ovarian cancer. In about half of

Read more

Common Genetic Test Often Wrong When Identifying Rare Disease-Causing Variants Such as BRCA1 and BRCA2, Study Says

February 16, 2021 10:00 am

By Sandee LaMotte, CNN

A genetic test used to detect common traits many people share is not reliable in identifying rare disease-causing variations, such as those that can predict breast and ovarian cancer, a new study has found.

The SNP … Read more

How Does Ovarian Cancer Form? A New Study Points to MicroRNA

July 30, 2020 4:00 pm

Although ovarian cancer is the fifth-leading cause of death from cancer in women, scientists don’t have a good handle on how it forms. Now a new study suggests that a microRNA—a molecule made by cells to turn genes on … Read more

Universal BRCA Testing Could Prevent Countless Cancer Deaths

July 17, 2020 1:00 pm

By Diana Swift

Population screening found to be cost-effective for higher income countries

Screening entire populations of women for mutations in breast and ovarian cancer susceptibility genes could prevent hundreds of thousands of cases in the U.S., and millions globally, … Read more

A White Paper on the Need for Consistent Terms for Testing in Precision Medicine

July 7, 2020 7:00 am

For years, The Clearity Foundation has emphasized the importance of tumor profiles/blueprints for informing decisions about treatment for ovarian cancer. Yet, genetic and tumor biomarker testing are not universally performed despite evidence that positive results in these tests could suggest … Read more

Convenient Spit Test Helps Women Assess Cancer Risk From The Comfort Of Their Own Homes

June 1, 2020 4:00 pm

By Stand Up To Cancer

Genetic testing for cancer risk can significantly improve the prevention or treatment of hereditary cancers, but studies have shown that people who might have a genetic risk often don’t get tested. A collaborative Stand Up … Read more

Study Findings Support the Use of Video-Assisted Genetic Counseling in Ovarian Cancer

March 31, 2020 10:00 am

By Susan Moench, PhD, PA-C

Results of a randomized clinical trial evaluating video-assisted genetic counseling followed by either formal genetic counseling or direct referral for genetic testing in women with ovarian/fallopian/peritoneal cancer receiving adjuvant therapy showed that a significantly higher … Read more

Pathogenic Variants in RAD51C and RAD51D Linked to Ovarian and Breast-Cancer Risk

March 7, 2020 10:00 am

By Will Boggs MD

NEW YORK (Reuters Health) – Pathogenic variants in RAD51C and RAD51D are associated with an increased risk of ovarian and breast cancer, researchers report.

“RAD51C and RAD51D are included in cancer gene panels that are widely … Read more

ASCO Guideline: Germline Testing Recommended for All Women Diagnosed With Epithelial Ovarian Cancer

February 6, 2020 11:00 am

By Susan Moench, PhD, PA-C

A central tenant of a recently issued American Society of Clinical Oncology (ASCO) guideline is that all women with a diagnosis of epithelial ovarian cancer should be offered testing for specific germline mutations associated with … Read more

PALB2 Linked to Increased Risk for Breast, Ovarian, and Pancreatic Cancer

January 8, 2020 10:00 am

By Christina Bennett, MS

Germline PALB2 pathogenic variants were associated with an increased risk for female breast cancer, male breast cancer, ovarian cancer, and pancreatic cancer, and these risks varied by age, according to data from an international study … Read more

New Name for Breast-Cancer Syndrome Could Help to Save Lives

July 3, 2019 6:00 pm

By Colin C. Pritchard

People of all sexes can have risk genes that are often assumed to affect only women. Renaming the syndrome should aid cancer prevention and treatment, argues Colin C. Pritchard.

I recently had a conversation with my … Read more

CRISPR Reveals New Cancer Drug Targets through ID of Critical Gene Fusion Regions

May 16, 2019 6:00 pm

In what they claim is the first large-scale systematic analysis of thousands of gene fusions in human cancers, scientists have identified a gene fusion that could represent a novel drug target for multiple cancers. Through their studies, the largely U.K.-based … Read more

Scientists Identify Genes Tied to Increased Risk of Ovarian Cancer

May 1, 2019 6:00 pm

A team of researchers at UCLA’s Jonsson Comprehensive Cancer, Cedars-Sinai Cancer and Dana-Farber Cancer Institute have newly identified 34 genes that are associated with an increased risk for developing the earliest stages of ovarian cancer. The findings, published today in … Read more

6 Questions to Ask Your Doctor After an Ovarian Cancer Diagnosis

April 30, 2019 5:00 pm

Two of the key points this article touches on refer to finding a clinical trial and seeking mental health support. At Clearity, we can help! Check out our Clinical Trial Finder, as well as Steps Through OC, a Read more