Ovarian Cancer Patients Undertested for Mutations that Could Guide Clinical Care

April 9, 2019 4:00 pm

By Krista Conger

A large study of women with breast and ovarian cancer has revealed significant gaps between national guidelines for genetic testing and actual testing practices, according to researchers from Stanford and five other institutions.

Fewer than a quarter … Read more

23andMe DTC Breast and Ovarian Cancer Risk Test Misses Almost 90 Percent of BRCA Mutation Carriers

April 5, 2019 5:00 pm

By Julia Karow

A study led by researchers at Invitae has found that 23andMe’s direct-to-consumer BRCA test, which tests for three common variants in the BRCA1 and BRCA2 genes and is authorized by the US Food and Drug Administration, misses … Read more

Study: Birth Control Pills Protect Against Aggressive Ovarian Cancer

April 3, 2019 5:00 pm

“The longer the history of oral contraceptive use, the greater the protection we observed in terms of reduced chance of dying from aggressive ovarian cancer,” said study first author Jennifer Mongiovi.

The protection that birth control pills offer against ovarian … Read more

SGO 2019: Less Worry, More Symptoms and Regret With Risk-Reducing Salpingo-Oophorectomy

March 20, 2019 5:00 pm

By Christina Bennett, MS

Women at increased risk for hereditary ovarian cancer who underwent risk-reducing salpingo-oophorectomy experienced less worry but worse menopausal symptoms and more regret compared with those who underwent salpingectomy with delayed oophorectomy, the Women Choosing Surgical Prevention … Read more

New Class of Drugs Could Treat Ovarian Cancer

March 19, 2019 5:00 pm

A team of researchers across The University of Manchester have shown that a new class of drugs are able to stop ovarian cancer cells growing.

The Cancer Research UK and Wellcome Trust funded study, published in the journal Cancer CellRead more

Individualized Dosing Regimen Reduces Side Effects in Ovarian Cancer Maintenance Therapy

March 18, 2019 7:00 pm

By Kristie L. Kahl

Side effects decreased among patients with high-risk ovarian cancer who received an individualized starting dose of Zejula (niraparib), based upon baseline bodyweight and platelet counts, compared with a fixed starting dose, according to a recent analysis

Read more

PARP Inhibitor Benefit Gets a TWiST in Recurrent Ovarian Cancer

March 17, 2019 6:00 pm

By Ian Ingram

In delaying disease progression in recurrent ovarian cancer, maintenance therapy with the PARP inhibitor niraparib (Zejula) also increased patients’ time without symptoms or toxicity (TWiST), an analysis of the phase III NOVA trial found.

Compared with placebo, … Read more

Cancer Biomarker for PARP Inhibitor Effectiveness Discovered

March 15, 2019 5:00 pm

Since tumors often have unique defects in the DNA damage response (DDR) pathway, identifying the molecular mechanisms that underlie how cells repair various DNA lesions is critical to selecting the appropriate clinical treatments. Inhibitors to poly-(ADP-ribose) polymerase (PARP) are examples … Read more

Ovarian Cancer Survivors Carry Burden of Severe Long-Term Fatigue

March 14, 2019 5:00 pm

By Will Pass

Women who have survived epithelial ovarian cancer (EOC) more often report severe long-term fatigue than healthy women, according to a case-control study involving more than 600 individuals.

Ovarian cancer survivors had a higher rate of sleep disturbance, … Read more

New Device Can Detect Cancer in Just a Drop of Blood

February 26, 2019 5:00 pm

By Maria Cohut

Some types of cancer, such as ovarian cancer, tend to remain undetected until they are too advanced for treatment to be effective. Now, an innovative tool may be able to detect cancer easily, quickly, and in minuscule … Read more

Could Conservative Management of Adnexal Masses Lead to Ovarian Cancer?

February 20, 2019 5:00 pm

By Dave Levitan

Conservative management of adnexal masses classified as benign was associated with a low risk of subsequent malignant ovarian cancer, according to a new study.

“Adnexal masses are often detected incidentally and most of them prove to be … Read more

AI Predicts Ovarian Cancer Survival Rates From CT Scans

February 15, 2019 5:00 pm

By Melissa Rohman

AI can predict a woman’s survival rate and response to treatments for ovarian cancer more accurately than current methods, according to research published online Feb. 15 in Nature Communications. 

The machine learning software developed by researchers at … Read more

Ovarian Cysts Should Be ‘Watched’ Rather Than Removed

February 5, 2019 5:00 pm

Women may not need to undergo surgery for non-cancerous ovarian cysts, avoiding potential surgical complications.

This is the finding of new research, by a team of international scientists from institutions including Imperial College London and KU Leuven, published in The Read more

Drug Treating Breast Cancer May Be Effective in Treating Lung and Ovarian Cancer

February 5, 2019 4:00 pm

Two new papers, published simultaneously in Nature Communications and led by researchers at McGill University, offer promise that a drug currently used to treat estrogen positive breast cancer may be effective in treating two different types of cancer, one rare … Read more

Drug Target Identified for Chemotherapy-Resistant Ovarian, Breast Cancer

February 4, 2019 5:00 pm

By Tamara Bhandari

Study finds mimic for BRCA genes that could be targeted to improve treatment

People who inherit a faulty copy of the so-called “breast cancer genes” BRCA1 and BRCA2 are at high risk of cancer. About 10 percent … Read more

Energizing the Immune System to Eat Cancer

January 21, 2019 3:00 pm

Immune cells called macrophages are supposed to serve and protect, but cancer has found ways to put them to sleep. Now researchers at the Abramson Cancer Center of the University of Pennsylvania say they’ve identified how to fuel macrophages with … Read more

AI Tool Scans Tumour Shape to Detect Aggressive Ovarian Cancer

January 15, 2019 12:30 am

Researchers at The Institute of Cancer Research, London (ICR) have developed an artificial intelligence (AI) test that analyses the shape of tumour cells to identify patients with aggressive ovarian cancer.

The test is intended to enable tailored treatment based on … Read more

Palliative Care May Improve Survival, Quality of Life in Advanced Cancer

January 14, 2019 5:30 pm

By Brielle Benyon

Recent research found that outpatient palliative care improved survival and quality of life in patients with advanced cancer.

Palliative care may boost survival in patients with advanced cancer, according to recent research conducted at Tulane University.

“If … Read more

PCOS May Increase Overall Cancer Risk

December 13, 2018 5:00 pm

By Regina Schaffer

Swedish women with polycystic ovary syndrome are 15% more likely to develop any cancer vs. women without the condition, with risk further elevated for cancers of the endometrium, ovary, pancreas and kidney, according to a research letter … Read more

Cancer DNA Binds to Gold. That Could Lead to New Cancer Blood Test.

December 5, 2018 7:30 pm

By Rachael Rettner, Senior Writer

Researchers have discovered a curious difference between the DNA from cancer cells and that from healthy cells, and this finding could lead to a new blood test for cancer.

The difference? Cancer DNA has a … Read more