Examining factors that may impact ovarian cancer survival disparities

June 20, 2022 10:33 am

by Coco Davis/ Fred Hutchinson Cancer Research Center

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy among women in the United States (US). Although the incidence rate is higher among White women, Black women have the lower survival … Read more

Real-World Data Identify Significant Differences in Tolerability Among Approved PARP Inhibitors in Ovarian Cancer

June 14, 2022 11:57 am

by Lindsey Fischer

A real-world analysis showed that the proportion of women with ovarian cancer who required dose modifications or treatment discontinuations while receiving PARP inhibitors differed significantly between olaparib, niraparib, and rucaparib.

Patients with ovarian cancer treated with FDA-approved

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Break Through Cancer Announces $50 Million in Grants to Researchers From Five Top Cancer Research Centers

April 19, 2022 9:13 am

by the ASCO Post Staff

Today, 1 year after its founding, Break Through Cancer announced $50 million in grants to support several cutting-edge research projects using a novel “TeamLab” structure—designed to maximize interdisciplinary collaboration among researchers at Dana-Farber Cancer Institute, … Read more

New Clue to Risk of Peritoneal Cancer After Prophylactic Salpingo-Oophorectomy

April 5, 2022 3:27 pm

by Charles Bankhead

— Women with BRCA variant and serous tubal intraepithelial carcinoma had a 34-fold greater risk

The presence of serous tubal intraepithelial carcinoma (STIC) at the time of risk-reducing salpingo-oophorectomy (RRSO) significantly increased the risk of peritoneal carcinomatosis … Read more

MAPK mutations linked to longer survival in ovarian cancer subset

March 24, 2022 10:43 am

by Jennifer Southall

 

Women with mitogen-activated protein kinase-mutated low-grade serous ovarian/peritoneal carcinoma experienced significantly longer PFS and OS compared with women without these mutations, according to study results.

The findings, presented during the Society of Gynecologic Oncology 2022 Annual … Read more

Researchers Use US to Predict Ovarian Cancer

March 22, 2022 11:13 am

Approach can help radiologists in a busy clinical practice assess lesions more quickly

The appearance of ovarian lesions on ultrasound is an effective predictor of cancer risk that can help women avoid unnecessary surgery, according to a new study published … Read more

Ovarian Cancer Patients in PARP Inhibitor Trials Don’t Reflect Real-World Population

February 25, 2022 11:33 am

by Jonathan Goodman, MPhil

Hispanic and Non-Hispanic Black patients were significantly underrepresented, but Asian/Pacific Islander patients were overrepresented.

Clinical trials of PARP inhibitors in patients with ovarian cancer do not accurately reflect the racial and ethnic makeup of the real-world … Read more

Virtual Surveillance Visits with Symptom, Serum CA-125 Review May Offer Alternative for Ovarian Cancer Recurrence Detection.

February 1, 2022 12:37 pm

by Monica Janke, MD

In patients with ovarian cancer and pretreatment elevated CA-125 who achieved remission after frontline therapy, most recurrences are detected by rising CA-125 levels or symptoms.

In patients with ovarian cancer and pretreatment elevated CA-125 who achieved

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Racial Disparities Persist in Ovarian Cancer Treatment

January 25, 2022 8:52 am

by Jon Kelvey

Black patients with ovarian cancer were less likely than their White counterparts to receive adjuvant chemotherapy after primary surgery, according to a study published in Gynecologic Oncology.

The study also showed that patients who did not undergo … Read more

Biomarkers Found for Platinum Resistance in Gynecologic Cancer

November 19, 2021 11:56 am

Blood-based metabolic signatures may predict whether women with ovarian or uterine cancer will respond well to platinum-based chemotherapy, according to a study by researchers in the Department of Gynecology at the Federal University of São Paulo’s Medical School (EPM-UNIFESP) in … Read more

Women with genetic mutations fare no worse with breast or ovarian cancer, study finds

October 1, 2021 12:00 am

By Krista Conger

Newly diagnosed breast or ovarian cancer patients who carry common cancer-associated mutations have similar or better short-term survival rates than those with no mutations, researchers report.

Women newly diagnosed with breast or ovarian cancer who are also … Read more

Biomarker May Help to Predict Response to Gemcitabine for Patients With High-Grade Serous Ovarian Cancer

September 30, 2021 2:05 am

By The ASCO Post Staff

For more than 2 decades, the chemotherapy agent gemcitabine has been a mainstay treatment for several types of cancer. Now, scientists have uncovered genetic evidence of which patients with high-grade serous ovarian cancer are likely … Read more

Improving Social Needs For Women With Gynecological Cancer Could Improve Outcomes and Lessen Healthcare Disparities

August 4, 2021 4:04 pm

By Ariana Pelosci

Women with gynecologic cancer who experience an improvement of social needs such as companionship and food insecurity could experience improved outcomes.

The identification of social needs and accompanying solutions could result in more actionable health care disparities … Read more

Virtual biopsies may give more accurate results than traditional method thanks to revolutionary technique

July 11, 2021 3:17 pm

CAMBRIDGE, England — Virtual biopsies could replace invasive tissue procedures and give more accurate results thanks to a revolutionary new method developed using computer scans. The new advanced computing technique uses routine medical scans to enable doctors to take fewer, … Read more

‘Devastated and Sad’ After 36 Years of Research — Early Detection of Ovarian Cancer Doesn’t Save Lives

May 19, 2021 1:00 pm

By Professor Ian Jacobs

I was motivated to improve the outcome for women with ovarian cancer by my experience as a junior doctor in London in 1985. But 36 years on, the results aren’t what we’d hoped.

My colleages’ and

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Disappointment: Screening for Ovarian Cancer Does Not Cut Deaths

May 13, 2021 12:00 pm

By Pam Harrison

Results from a huge British trial that involved more than 200,000 women who were followed for a median of 16 years have turned out negative. Investigators found that annual screening for ovarian cancer with either multimodal screening … Read more

Smart Cell Therapies for Solid Cancers Ready to Move Toward Clinical Trials

April 28, 2021 7:00 pm

By Lindzi Wessel

Immunotherapies that fight cancer have been a life-saving advancement for many patients, but the approach only works on a few types of malignancies, leaving few treatment options for most cancer patients with solid tumors. Now, in two Read more

HIPEC Combo Doubles PFS in Advanced Ovarian Cancer

March 26, 2021 12:00 pm

Cisplatin/paclitaxel boosts outcomes without increasing complications in registry study.

By Charles Bankhead

Two drugs outperformed one for hyperthermic intraperitoneal chemotherapy (HIPEC) after interval surgical debulking of advanced ovarian cancer, data from a prospective registry showed.

Median progression-free survival (PFS) doubled … Read more

Moffitt Researchers Discover Mechanism that Regulates Anti-Tumor Activity of Immune Cells

February 3, 2021 3:00 am

The study finally paves the way for the use of antibodies different from IgG as immunotherapeutic agents for at least tumors currently resistant to conventional immune checkpoint blockade.

The prognosis of ovarian cancer is poor, with an estimated five-year survival … Read more

‘Virtual Biopsies’ Could Replace Tissue Biopsies in Future Thanks to Technique Developed by Cambridge Scientists

January 6, 2021 5:00 am

A new advanced computing technique using routine medical scans to enable doctors to take fewer, more accurate tumour biopsies, has been developed by cancer researchers at the University of Cambridge. This is an important step towards precision tissue sampling for

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