Merck, Pfizer’s Bavencio Misses Ovarian Cancer Trial Endpoints

November 26, 2018 7:45 pm

By Selina McKee

A late-stage study testing Merck KGaA and Pfizer’s PD-L1 antibody Bavencio has failed to meet its primary endpoints in patients with certain forms of ovarian cancer.

The drug was being tested as monotherapy and in combination with … Read more

Cancer Patients Struggle to Understand Clinical Trials

September 10, 2017 5:40 pm

Cancer patients struggle to understand what is involved in a clinical trial, even when they have participated in them. In a survey of 1090 adult cancer patients, more than half did not understand the concepts of clinical equipoise or randomization.… Read more

A Cancer Conundrum: Too Many Drug Trials, Too Few Patients

August 16, 2017 3:25 pm

With the arrival of two revolutionary treatment strategies, immunotherapy and personalized medicine, cancer researchers have found new hope — and a problem that is perhaps unprecedented in medical research.

There are too many experimental cancer drugs in too many clinical … Read more

Clinical Trials Are the Way Forward for Ovarian Cancer

July 13, 2017 6:44 pm

For women with ovarian cancer, the message is clear: participating in clinical trials, even early-phase ones, offers the best hope for better treatments, but efforts are urgently needed at every level to ensure that more of these research opportunities are … Read more

ImmunoGen Drug Moving Ahead In Single-Agent, Combination Trials

May 19, 2017 7:13 pm

Latest results from a mid-stage trial of ImmunoGen Inc’s experimental antibody-drug conjugate show that it shrinks or stabilizes tumors in nearly half of advanced ovarian cancer patients with at least medium levels of a key biomarker whose disease has become Read more

Recruitment Begins for World’s First Ovarian Cancer Vaccine Trial

April 21, 2017 6:16 pm

UConn Health is beginning to recruit patients for the world’s first personalized genomics-driven ovarian cancer vaccine clinical trial. The goal: to prevent an often deadly relapse of the disease in women diagnosed at advanced stages.

The pioneering injectable vaccine OncoImmunome … Read more

Knowledge and Good Decision Making Tools for Ovarian Cancer Patients

March 8, 2017 11:00 pm

By: Annette McElhiney

As a retired college professor, I firmly believe that knowledge is power and may also result in a longer healthier life. In a recent Wall Street Journal article, “How to Get Patients to Take More Control Read more

New Clinical Trial Combines Two Methods to Defeat Ovarian Cancer

January 12, 2017 3:31 am

Fewer than half of women diagnosed with ovarian cancer live for five years or more. Sarah Adams, MD, a cancer doctor at the UNM Comprehensive Cancer Center, hopes a new therapy that delivers a one-two punch to cancer cells will … Read more

Precision Medicine Yields Better Outcomes for Clinical Trial Patients

June 2, 2016 6:21 pm

A meta-analysis of 346 phase I clinical trials involving more than 13,000 patients found that patients whose treatment was selected based on the molecular characteristics of their tumor had significantly better outcomes. The study was featured in a press briefing … Read more

F.D.A. Regulator, Widowed by Cancer, Helps Speed Drug Approval

January 5, 2016 9:37 pm

Mary Pazdur had exhausted the usual drugs for ovarian cancer, and with her tumors growing and her condition deteriorating, her last hope seemed to be an experimental compound that had yet to be approved by federal regulators.

So she appealed … Read more