Why Some Cancers May Respond Poorly to Key Drugs Discovered

September 22, 2020 4:00 pm

Patients with BRCA1/2 mutations are at higher risk for breast, ovarian and prostate cancers that can be aggressive when they develop—and, in many cases, resistant to lifesaving drugs. Now scientists at The University of Texas at Austin and Ajou University … Read more

Research Discovery May Offer New Treatment Options for People Diagnosed With Rare Form of Ovarian Cancer

August 26, 2020 8:00 am

A recent finding by researchers at UBC’s faculty of medicine and the BC Cancer Research Institute (BCCRI) may offer a new treatment possibility for people diagnosed with a rare and aggressive form of ovarian cancer.

Small cell carcinoma of the … Read more

STING Activation Touted as Potential Immunotherapy for Cancer

August 25, 2020 9:00 am

A Scripps Research team reports the discovery of a molecule that can activate a natural immune-boosting protein called STING. The findings mark a key advance in the field of oncology, as the STING protein is known for its strong antitumor … Read more

Tumor Gene Test Could Help to Predict Ovarian Cancer Prognosis

August 17, 2020 6:00 pm

A global team of medical researchers led by UNSW have developed a test that could help to predict survival for women diagnosed with ovarian cancer, and pave the way towards personalised treatment.

A tumour test could help to identify ovarian … Read more

Study Finds Patients With Rare Ovarian Cancer Develop Chemoresistance

August 7, 2020 5:00 pm

By Christina Bennett, MS

Patients with LGSC also had a significantly lower partial response rate with neoadjuvant therapy compared with patients with HGSC.

Patients with low-grade serous carcinoma of the ovary or peritoneum (LGSC) developed chemoresistance to neoadjuvant platinum-based therapy,

Read more

How Does Ovarian Cancer Form? A New Study Points to MicroRNA

July 30, 2020 4:00 pm

Although ovarian cancer is the fifth-leading cause of death from cancer in women, scientists don’t have a good handle on how it forms. Now a new study suggests that a microRNA—a molecule made by cells to turn genes on … Read more

Chemotherapy, Surgery for Gynecologic Cancer Not Linked to Higher COVID-19 Mortality Risk

July 30, 2020 3:00 pm

Women who underwent chemotherapy or surgery for gynecologic cancer and also had COVID-19 infection did not appear at significantly increased risk for death due to the novel coronavirus, according to study findings published in Cancer.

However, recent immunotherapy use … Read more

Study: L-Grb2 Has Therapeutic Efficacy in Preclinical Models of Ovarian and Uterine Cancer

July 23, 2020 3:00 pm

The cover for issue 29 of Oncotarget features, “In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model,” by Lara, et al. which reported that adaptor proteins such as growth factor … Read more

Study Finds Women with Gynecologic Cancers Have Significant Fatigue After Surgery

July 22, 2020 4:00 pm

These results suggest the need for future studies to examine scalable interventions to improve fatigue in women with gynecologic cancers.

By Hannah Slater

A 1-year longitudinal study published in Cancer suggested that almost half of women with gynecologic cancers had

Read more

Universal BRCA Testing Could Prevent Countless Cancer Deaths

July 17, 2020 1:00 pm

By Diana Swift

Population screening found to be cost-effective for higher income countries

Screening entire populations of women for mutations in breast and ovarian cancer susceptibility genes could prevent hundreds of thousands of cases in the U.S., and millions globally, … Read more

Ovarian Cancer Metastasis Study Identifies Important Protein with Potential as Diagnostic Tool and Treatment Option

July 16, 2020 3:00 pm

By Clayton Boldt, Ph.D

Advanced ovarian cancer most commonly metastasizes to the omentum, a layer of fatty tissue that wraps around and protects internal organs in the abdomen, but the reasons for this have not been well-understood. In a new … Read more

Surgical Removal of Fallopian Tubes to Prevent Ovarian Cancer Rapidly Rising, More Research Needed to Support Its Continued Use

July 13, 2020 6:00 pm

Ten percent of women who received a hysterectomy and salpingectomy, or removal of the fallopian tubes, during the study period had a family history of breast or ovarian cancer.

By Ryan McDonald

Despite limited data to support its use, the … Read more

Blood Test Detects Dozens of Cancer Types, Often Before Symptoms Emerge

July 13, 2020 5:00 pm

A novel blood test accurately detected more than 50 types of cancer with a specificity of 99.3%.

By Mark Leiser

A novel blood test accurately detected more than 50 types of cancer with a specificity of 99.3%, according to results … Read more

Study: The Immune Effects of Seclidemstat in Aggressive Ovarian Cancer Striking Young Women

July 13, 2020 3:00 pm

A drug known as SP-2577 could help enable the body’s own immune system to attack ovarian cancer, according to a study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.

Published today in the scientific … Read more

New Cancer Vaccine Ready for Human Trials

July 10, 2020 6:00 pm

According to new research published in Clinical and Translational Immunology, a new cancer vaccine is ready for human trials following its success in preclinical studies.

By Alana Hippensteele

The vaccine was recently developed by a research team based at The … Read more

Pap Tests May Hold Biomarkers Ahead of Ovarian Cancer Diagnosis

July 10, 2020 4:00 pm

High-grade serous epithelial ovarian cancer may be detected earlier in the course of the disease by testing for TP53 clonal variants in DNA from Pap tests.

By Leah Lawrence

High-grade serous epithelial ovarian cancer may be detected earlier in the … Read more

This MicroRNA Might Help Detect, Treat Ovarian Cancer

June 26, 2020 6:00 pm

In cell and mouse models, miR-181a showed promise as a biomarker for early stage ovarian cancer and may help make immunotherapy treatment more effective.

By Ian Demsky

A microRNA that is normally involved in immune cell differentiation helps to initiate

Read more

Neoadjuvant Chemotherapy Increases Immunogenicity of High-Grade Serous Ovarian Cancer

June 23, 2020 9:00 am

By Susan Moench, PhD, PA-C

High-grade serous ovarian cancer (HGSOC) is characterized by a high level of intrinsic heterogeneity in the tumor-immune microenvironment that is modified by chemotherapy, according to findings published in Nature Genetics.

HGSOC, a common and … Read more

Treatment with Lipophilic Statins Shows Lower Mortality Rate for Patients with Epithelial Ovarian Cancer

June 22, 2020 6:00 pm

A study presented at the AACR Virtual Annual Meeting II showed a significant decrease in mortality rate for patients with epithelial ovarian cancer when treated with lipophilic statins, supporting the further evaluation of statins to treat ovarian cancer in randomized Read more

Single-Cell Analysis of Ovarian Cancer Points to Potential Treatment Avenue

June 22, 2020 10:00 am

Inhibiting the JAK/STAT pathway could represent a potential treatment for high-grade serous ovarian cancer, according to a single-cell analysis.

Researchers led by the Broad Institute’s Aviv Regev used single-cell RNA sequencing (scRNA-seq) to analyze about 11,000 cells from ascites from … Read more