ctDNA Offers Potential Biomarker for PARP Inhibitor Maintenance Therapy in Epithelial Ovarian Cancer

March 20, 2024 9:00 am

Clearity’s Perspective: At the SGO meeting several presentations described how circulating tumor DNA (ctDNA) may be a new, personalized, sensitive tool to help evaluate treatment de-escalation, monitor minimal residual disease (MRD), and track treatment response in ovarian cancer. The application Read more

New microbiome insights could help boost immunotherapy for a range of rare cancers

March 1, 2024 9:00 am

Clearity’s Perspective: Previous research in different types of cancer has suggested that there is a relationship between a cancer patient’s gut microbiota (microorganisms that live in the digestive tract) composition and the response to immune checkpoint inhibitor therapy; however,

Read more

Cancer Prevention Strategies Linked to Mortality Reduction in BRCA Carriers

February 29, 2024 9:00 am

By Mike Basset

Risk management strategies including bilateral salpingo-oophorectomy (BSO) for ovarian cancer and MRI surveillance for breast cancer were associated with a significant reduction in mortality for women with BRCA1/2 sequence variations, according to results from two cohort studies … Read more

Study Shows Disparities in Psychosocial Outcomes Among Women With Ovarian Cancer in Rural vs Urban Areas

February 23, 2024 9:00 am

Clearity’s Perspective: Clearity offers emotional support to people with ovarian cancer and their caregivers through our Steps Through OC program. If you would like personal one-to-one assistance with the stress and challenges associated with an ovarian cancer diagnosis, our team Read more

This Could Be a Strong Weapon for Cancer Pain (or Any Pain)

February 21, 2024 9:00 am

By Courtney Southwick

Exercising for upwards of 30 minutes most days may help relieve pain in patients who’ve been diagnosed with cancer, according to a study of exercise and pain outcomes from more than 60,000 people, including 10,000 with a … Read more

Diagnosing the “Silent Killer”: AI Tackles Early Stage Ovarian Cancer

January 26, 2024 9:00 am

By Fay Lin, PhD

A major bottleneck in early detection is the molecular heterogeneity between ovarian cancer (OC) patients, which limits the likelihood of identifying individual biomarkers that are shared among patients. In a new study “A personalized probabilistic Read more

Real-World Data Confirm the Incidence of ADC-Related Ocular Toxicities in Ovarian Cancer

January 26, 2024 9:00 am

By Ashling Wahner

Although the antibody-drug conjugate (ADC) mirvetuximab soravtansine-gynx (Elahere) is associated with a high rate of ocular toxicity in patients with folate receptor α (FRα)-positive, platinum-resistant ovarian cancer, the real-world incidence of this adverse effect (AE) in this … Read more

Gynecologic cancer clinical trial enrollment lower for certain underrepresented groups

December 29, 2023 9:00 am

By Erin T. Welsh, MA

Key takeaways:

  • Clinical trial enrollment was lower for Asian, Black and Hispanic women vs. white women.
  • Asian and Hispanic women were underrepresented in endometrial, cervical and ovarian cancer trials.

Asian, Black and Hispanic women with … Read more

Artificial Intelligence May Predict Ovarian Cancer Therapy Outcomes

November 21, 2023 9:00 am

By Rylan DeStefano

An artificial intelligence model called IRON (Integrated Radiogenomics for Ovarian Neoadjuvant therapy) shows an 80% accuracy rate in the prediction of therapy outcomes for patients with ovarian cancer. The artificial intelligence model focuses specifically on the volumetric … Read more

Scientists Piece Together DNA Repair Pathway Implicated in Breast, Ovarian, and Prostate Cancers

November 15, 2023 9:00 am

Clearity’s Perspective: Cancer cells that have mutations in BRCA or that are HRD-positive are not able to use the so-called homologous recombination repair pathway to fix mistakes in the cancer cell. These cancer cells become reliant on other repair pathways. Read more

Survey Finds Gaps in Care for Patients With Slow-Growing Ovarian Cancer

November 9, 2023 9:00 am

By Mary Caffrey

Delayed diagnoses. Symptoms that are dismissed or misinterpreted. Feelings of anxiety because no one can offer a clear explanation for their condition.

These are just some of the experiences of women who have low-grade serous ovarian cancer … Read more

Claudine Isaacs, MD, on the Limitations of At-Home Genetic Tests for Hereditary Breast/Ovarian Cancers

More than 95% of BRCA1 or BRCA1 pathogenic variants would have been missed by DTC testing, largest such study showed

November 8, 2023 9:00 am

By Mark Fuerst

Direct-to-consumer (DTC) genetic testing has limited use as a screening tool for identifying individuals at risk of hereditary breast or ovarian cancer, especially in those of non-Ashkenazi Jewish descent, researchers reported.

Most current DTC genetic tests evaluate … Read more

Multidisciplinary Surgical Team Approach Improves OS in Ovarian Cancer

November 1, 2023 9:00 am

By Hayden E. Klein

Patients with ovarian cancer saw a 70% improvement in overall survival (OS) 3 years after undergoing a multidisciplinary surgical approach compared with previous approaches to therapy, according to a study published in Annals of Surgical OncologyRead more

Common Chemo Drugs May Not Work as We Thought

October 27, 2023 9:00 am

Clearity’s Perspective: New research demonstrates how paclitaxel (Taxol), a commonly used and effective drug for OC, works by disrupting cancer cell division. This research helps us to get a better understanding of the mechanism through which paclitaxel (Taxol) destroys cancer Read more

Liquid Biopsy Shows Promise to Distinguish Benign Pelvic Masses from Tumorous Ones

October 11, 2023 9:00 am

A new liquid biopsy test developed by researchers at USC Norris Comprehensive Cancer Center has shown promise to distinguish which pelvic masses are benign and which are tumorous, a development that could aid early diagnosis of high-grade serous ovarian carcinoma … Read more

Integrating Acupuncture Into a Cancer Treatment Plan

September 27, 2023 9:00 am

Key Points:

  • Acupuncture is a medical technique rooted in Chinese medicine that has beenused for millennia to improve health and well-being.
  • Despite growing interest and increasing evidence for its effectiveness in reducing symptom burden, the use of acupuncture remains low
Read more

Experts urge study of psilocybin, other psychedelics for cancer-related distress

August 17, 2023 9:00 am

The prevalence of distress among women with late-stage gynecologic cancers calls for well-designed studies to assess the safety and efficacy of psychedelics for this patient population, according to authors of a published commentary.

Psychedelics — specifically psilocybin — have shown … Read more

Long DNA molecules reveal new scar types in HR-deficient cancers

August 16, 2023 9:00 am

DNA can be damaged by toxins, radiation, or even normal cell division, but human cells must continually fix DNA breaks to survive. In cells that cannot repair DNA effectively, changes (mutations) can occur that lead to cancer.

Most cells rely … Read more

Using the immune system to stop ovarian cancer

August 16, 2023 9:00 am

The search for preventions and cures has turned inward—focusing on the immune system to stop ovarian cancer.

Professor Paul Hertzog’s research group at Hudson Institute of Medical Research has been working to expand on their discovery of a naturally occurring … Read more

Proteomics Pathway Diagnostic Helps Identify Platinum-Refractory Ovarian Cancers

August 9, 2023 9:00 am

A new study describes a new diagnostic approach that could help identify the 15% of women with ovarian cancer whose tumors are intrinsically refractory to standard platinum-based therapies, the most common type of chemotherapy for the disease.

Most ovarian cancers … Read more