Program Helps Medically Underserved, Minority Cancer Survivors Be More Active

July 3, 2024 9:00 am

by Linda Wang

Physical activity can have many benefits for cancer survivors, from improving their quality of life to potentially making it less likely that their disease will come back. Yet studies have shown that many cancer survivors struggle to … Read more

Study Supports More Inclusive Clinical Trials With Broader Eligibility Criteria

—No difference in adverse events, clinical benefit, OS for patients with or without waivers

June 27, 2024 9:00 am

by Charles Bankhead

Patients who received protocol waivers in a clinical trial of targeted anticancer therapy had outcomes similar to those who met all enrollment criteria, a large retrospective review showed.

Patients who received waivers had a clinical benefit rate … Read more

Estrogen-Only Hormone Therapy Linked to Increased Gynecologic Cancer Risk, But Estrogen-Progestin Combination Therapy Lowers It

June 1, 2024 9:00 am

by Aaron Tallent

Key Points:

  • Hormone replacement therapy (HRT) can reduce bothersome symptoms of menopause, but there is concern it may increase the incidence of certain cancers.
  • An analysis from the Women’s Health Initiative shows that estrogen-only HRT may increase
Read more

Sydney researchers find differences in ovarian cancer risk factors by racial and ethnic groups

May 31, 2024 9:00 am

Researchers conducted an international study of more than 11,000 ovarian cancer cases found selected ovarian cancer risk factors vary for women of different racial and ethnic backgrounds.

Led by Dr Melissa Merritt and Dr Nicola Meagher from the Daffodil Centre … Read more

For some endometriosis-related ovarian cancers, timing is everything

May 28, 2024 9:00 am

by Van Andel Research Institute

Two types of endometriosis-related ovarian cancer arise from the same cells but likely at different stages of the menstrual cycle—a nuance that significantly influences treatment response, reports a recent study led by Van Andel Institute … Read more

Study reveals no survival benefit from systemic therapy in very advanced solid tumors

May 17, 2024 9:00 am

Clearity’s Perspective: Clearity knows that making decisions about continuing treatment when facing advanced ovarian cancer is complicated. Given the difficulty of these decisions, this article suggests having goals-of-care conversations with your medical providers when deciding whether or not to continue Read more

AI partners with liquid biopsy for ‘robust’ identification of women with ovarian cancer

April 10, 2024 9:00 am

by Josh Friedman

Key takeaways:

  • AI-analyzed fragmentomes and protein biomarkers better distinguished women with ovarian cancer in screening.
  • Liquid biopsy assay outperformed CA125 analysis alone.

An artificial intelligence-driven algorithm used a novel liquid biopsy assay to differentiate women with ovarian … Read more

Stress-Induced Immune Changes May Help Cancer Spread

April 2, 2024 9:00 am

Clearity’s Perspective: This article highlights the importance of learning ways to cope with and manage stress after an ovarian cancer diagnosis. The study, performed only on mice, suggests that there may be a link between overproduction of stress hormones and Read more

ctDNA Offers Potential Biomarker for PARP Inhibitor Maintenance Therapy in Epithelial Ovarian Cancer

March 20, 2024 9:00 am

Clearity’s Perspective: At the SGO meeting several presentations described how circulating tumor DNA (ctDNA) may be a new, personalized, sensitive tool to help evaluate treatment de-escalation, monitor minimal residual disease (MRD), and track treatment response in ovarian cancer. The application Read more

New microbiome insights could help boost immunotherapy for a range of rare cancers

March 1, 2024 9:00 am

Clearity’s Perspective: Previous research in different types of cancer has suggested that there is a relationship between a cancer patient’s gut microbiota (microorganisms that live in the digestive tract) composition and the response to immune checkpoint inhibitor therapy; however,

Read more

Cancer Prevention Strategies Linked to Mortality Reduction in BRCA Carriers

February 29, 2024 9:00 am

By Mike Basset

Risk management strategies including bilateral salpingo-oophorectomy (BSO) for ovarian cancer and MRI surveillance for breast cancer were associated with a significant reduction in mortality for women with BRCA1/2 sequence variations, according to results from two cohort studies … Read more

Study Shows Disparities in Psychosocial Outcomes Among Women With Ovarian Cancer in Rural vs Urban Areas

February 23, 2024 9:00 am

Clearity’s Perspective: Clearity offers emotional support to people with ovarian cancer and their caregivers through our Steps Through OC program. If you would like personal one-to-one assistance with the stress and challenges associated with an ovarian cancer diagnosis, our team Read more

This Could Be a Strong Weapon for Cancer Pain (or Any Pain)

February 21, 2024 9:00 am

By Courtney Southwick

Exercising for upwards of 30 minutes most days may help relieve pain in patients who’ve been diagnosed with cancer, according to a study of exercise and pain outcomes from more than 60,000 people, including 10,000 with a … Read more

Diagnosing the “Silent Killer”: AI Tackles Early Stage Ovarian Cancer

January 26, 2024 9:00 am

By Fay Lin, PhD

A major bottleneck in early detection is the molecular heterogeneity between ovarian cancer (OC) patients, which limits the likelihood of identifying individual biomarkers that are shared among patients. In a new study “A personalized probabilistic Read more

Real-World Data Confirm the Incidence of ADC-Related Ocular Toxicities in Ovarian Cancer

January 26, 2024 9:00 am

By Ashling Wahner

Although the antibody-drug conjugate (ADC) mirvetuximab soravtansine-gynx (Elahere) is associated with a high rate of ocular toxicity in patients with folate receptor α (FRα)-positive, platinum-resistant ovarian cancer, the real-world incidence of this adverse effect (AE) in this … Read more

Gynecologic cancer clinical trial enrollment lower for certain underrepresented groups

December 29, 2023 9:00 am

By Erin T. Welsh, MA

Key takeaways:

  • Clinical trial enrollment was lower for Asian, Black and Hispanic women vs. white women.
  • Asian and Hispanic women were underrepresented in endometrial, cervical and ovarian cancer trials.

Asian, Black and Hispanic women with … Read more

Artificial Intelligence May Predict Ovarian Cancer Therapy Outcomes

November 21, 2023 9:00 am

By Rylan DeStefano

An artificial intelligence model called IRON (Integrated Radiogenomics for Ovarian Neoadjuvant therapy) shows an 80% accuracy rate in the prediction of therapy outcomes for patients with ovarian cancer. The artificial intelligence model focuses specifically on the volumetric … Read more

Scientists Piece Together DNA Repair Pathway Implicated in Breast, Ovarian, and Prostate Cancers

November 15, 2023 9:00 am

Clearity’s Perspective: Cancer cells that have mutations in BRCA or that are HRD-positive are not able to use the so-called homologous recombination repair pathway to fix mistakes in the cancer cell. These cancer cells become reliant on other repair pathways. Read more

Survey Finds Gaps in Care for Patients With Slow-Growing Ovarian Cancer

November 9, 2023 9:00 am

By Mary Caffrey

Delayed diagnoses. Symptoms that are dismissed or misinterpreted. Feelings of anxiety because no one can offer a clear explanation for their condition.

These are just some of the experiences of women who have low-grade serous ovarian cancer … Read more