Cancer Discovery Could Revive Failed Treatments for Solid Tumors

April 5, 2021 11:00 am

New research from the UVA Cancer Center could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials.

The research from UVA’s Jogender Tushir-Singh, PhD, explains why … Read more

HIPEC Combo Doubles PFS in Advanced Ovarian Cancer

March 26, 2021 12:00 pm

Cisplatin/paclitaxel boosts outcomes without increasing complications in registry study.

By Charles Bankhead

Two drugs outperformed one for hyperthermic intraperitoneal chemotherapy (HIPEC) after interval surgical debulking of advanced ovarian cancer, data from a prospective registry showed.

Median progression-free survival (PFS) doubled … Read more

High Tumor Mutational Burden Predicts Immunotherapy Response in Some—but Not All—Cancers

March 16, 2021 6:00 pm

High tumor mutational burden (TMB) was useful for predicting clinical responses to immune checkpoint inhibitors only in a subset of cancer types, according to a study published by McGrail et al in Annals of Oncology.

The findings suggest that … Read more

Cancer Patients Shouldn’t Let Imaging Concerns Delay COVID-19 Vaccine

March 3, 2021 7:00 pm

By Lisa Rapaport

Patients with cancer shouldn’t delay COVID-19 vaccination despite the potential for clinically evident adenopathy on imaging done after vaccination, according to recommendations from a multidisciplinary panel of scientific experts.

Vaccination-associated adenopathy or axillary swelling may appear within … Read more

Pap Test/Cervical Swab Samples Can Reveal Ovarian Cancer Biomarkers

February 22, 2021 10:00 am

 Sharon Worcester

Residual fixatives from liquid-based Pap tests and cervical swabs contain tumor-specific biomarkers for ovarian cancer, according to an analysis of proteins found in matched biospecimens from a woman with high grade serous ovarian cancer.

The findings suggest … Read more

Proton Therapy Induces Biologic Response to Attack Treatment-Resistant Cancers

February 17, 2021 4:00 pm

Mayo Clinic researchers have developed a novel proton therapy technique to more specifically target cancer cells that resist other forms of treatment. The technique is called LEAP, an acronym for “biologically enhanced particle therapy.” The findings are published today in … Read more

Improving Cancer Immunotherapy by Blocking Glucose Supply

February 17, 2021 11:00 am

All cells use sugar as a vital source of energy and building blocks. Unfortunately, that means even cancer cells use sugar. Researchers at Memorial Sloan Kettering (MSK) Cancer Center wondered what happens when tumor cells and immune cells battle for … Read more

Moffitt Researchers Discover Mechanism that Regulates Anti-Tumor Activity of Immune Cells

February 3, 2021 3:00 am

The study finally paves the way for the use of antibodies different from IgG as immunotherapeutic agents for at least tumors currently resistant to conventional immune checkpoint blockade.

The prognosis of ovarian cancer is poor, with an estimated five-year survival … Read more

Nulliparity, Not ART, Likely Raises Risk of Ovarian Cancer

January 19, 2021 5:00 pm

By Mark L. Fuerst

Women who receive ovarian stimulation for assisted reproductive technology (ART) procedures don’t have an increased risk of developing ovarian cancer when compared to subfertile women who don’t undergo ART, according to a new study.

The results … Read more

Link Between Driver of Ovarian Cancer and Metabolism Opens Up New Therapeutic Strategies

January 11, 2021 3:00 pm

Loss of ARID1A causes increased glutamine metabolism, which can be blocked pharmacologically to target ARID1A-mutant tumors.

Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according … Read more

‘Virtual Biopsies’ Could Replace Tissue Biopsies in Future Thanks to Technique Developed by Cambridge Scientists

January 6, 2021 5:00 am

A new advanced computing technique using routine medical scans to enable doctors to take fewer, more accurate tumour biopsies, has been developed by cancer researchers at the University of Cambridge. This is an important step towards precision tissue sampling for

Read more

PARP Inhibitors Linked With Blood Cancer Risk

December 28, 2020 11:00 am

Incidence of MDS/AML under 1%, but further investigation warranted as indications broaden

By Leah Lawrence

Although rare, poly-ADP ribose polymerase (PARP) inhibitors were associated with an increased risk for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and occurred even … Read more

Oral Contraceptive Pills Protect Against Ovarian and Endometrial Cancer, Study Finds

December 18, 2020 11:00 am

A study has shown that the use of oral contraceptives gave women a much lower risk of developing both ovarian and endometrial cancer.

A study involving more than 250,000 women has shown that the use of oral contraceptives can protect … Read more

Elevated Stress Hormone Levels Could Reawaken Dormant Cancer Cells, Study Finds

December 2, 2020 5:00 pm

By Shraddha Chakradhar

The recurrence of cancer months or even years after successful treatment is an all too common phenomenon, and scientists have been chipping away at understanding how undetectable cells can once again unleash disease on the body — … Read more

SEngine Precision Medicine IDs Potential Ovarian Cancer Treatment Combos Using Organoid Approach

November 23, 2020 8:00 pm

By Caroline Hopkins

Using organoids that closely model certain features of ovarian tumors, researchers have identified and tested treatment combinations that may benefit patients, many of whom experience acquired or de novo resistance to PARP inhibitors.

In a study recently … Read more

In Vitro Fertilization Does Not Increase the Risk of Ovarian Cancer

November 20, 2020 7:00 pm

A new paper published in JNCI: Journal of the National Cancer Institute indicates that receiving assisted reproductive technology does not increase the risk women have for developing ovarian cancer.

Previous research indicated that women who use assisted reproductive technology in Read more

Revolutionary CRISPR-Based Genome Editing System Treatment Destroys Cancer Cells

November 18, 2020 4:00 pm

TAU breakthrough may increase life expectancy in brain and ovarian cancers.

Researchers at Tel Aviv University (TAU) have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure … Read more

ASCO Advises Against PARP Inhibitor Retreatment in Ovarian Cancer

October 28, 2020 4:00 pm

By Andrew D. Bowser

New guidelines recommend against retreatment with poly (ADP-ribose) polymerase (PARP) inhibitors in women with epithelial ovarian, tubal, or primary peritoneal cancer (EOC). However, trials investigating retreatment are underway, so this recommendation may change.

The guidelines, from … Read more

KSQ Boosts PARP Inhibition In Models Of Cancer With USP1 Inhibitor

October 27, 2020 7:00 pm

KSQ Therapeutics is hoping to provide hope for ovarian and breast cancer patients that have developed a resistance to drugs and those who don’t respond at all by developing a drug that may be able to boost the effectiveness of … Read more

Two-Stage Surgery to Reduce Ovarian Cancer Risk Piques Interest

October 16, 2020 6:00 pm

 Sharon Worcester

“Many physicians would assume that prevention of cancer, especially cancer as serious as ovarian cancer, trumps all other decision making, but when we really listen to high-risk women, they want to have options,” Karen Lu, MD, … Read more