All Posts
Diagnosing the “Silent Killer”: AI Tackles Early Stage Ovarian Cancer
January 26, 2024 9:00 amBy Fay Lin, PhD
A major bottleneck in early detection is the molecular heterogeneity between ovarian cancer (OC) patients, which limits the likelihood of identifying individual biomarkers that are shared among patients. In a new study “A personalized probabilistic … Read more
Real-World Data Confirm the Incidence of ADC-Related Ocular Toxicities in Ovarian Cancer
January 26, 2024 9:00 amBy Ashling Wahner
Although the antibody-drug conjugate (ADC) mirvetuximab soravtansine-gynx (Elahere) is associated with a high rate of ocular toxicity in patients with folate receptor α (FRα)-positive, platinum-resistant ovarian cancer, the real-world incidence of this adverse effect (AE) in this … Read more
Gynecologic cancer clinical trial enrollment lower for certain underrepresented groups
December 29, 2023 9:00 amBy Erin T. Welsh, MA
Key takeaways:
- Clinical trial enrollment was lower for Asian, Black and Hispanic women vs. white women.
- Asian and Hispanic women were underrepresented in endometrial, cervical and ovarian cancer trials.
Asian, Black and Hispanic women with … Read more
Artificial Intelligence May Predict Ovarian Cancer Therapy Outcomes
November 21, 2023 9:00 amBy Rylan DeStefano
An artificial intelligence model called IRON (Integrated Radiogenomics for Ovarian Neoadjuvant therapy) shows an 80% accuracy rate in the prediction of therapy outcomes for patients with ovarian cancer. The artificial intelligence model focuses specifically on the volumetric … Read more
Scientists Piece Together DNA Repair Pathway Implicated in Breast, Ovarian, and Prostate Cancers
November 15, 2023 9:00 amClearity’s Perspective: Cancer cells that have mutations in BRCA or that are HRD-positive are not able to use the so-called homologous recombination repair pathway to fix mistakes in the cancer cell. These cancer cells become reliant on other repair pathways. … Read more
Survey Finds Gaps in Care for Patients With Slow-Growing Ovarian Cancer
November 9, 2023 9:00 amBy Mary Caffrey
Delayed diagnoses. Symptoms that are dismissed or misinterpreted. Feelings of anxiety because no one can offer a clear explanation for their condition.
These are just some of the experiences of women who have low-grade serous ovarian cancer … Read more
Claudine Isaacs, MD, on the Limitations of At-Home Genetic Tests for Hereditary Breast/Ovarian Cancers More than 95% of BRCA1 or BRCA1 pathogenic variants would have been missed by DTC testing, largest such study showed
November 8, 2023 9:00 am By Mark Fuerst
Direct-to-consumer (DTC) genetic testing has limited use as a screening tool for identifying individuals at risk of hereditary breast or ovarian cancer, especially in those of non-Ashkenazi Jewish descent, researchers reported.
Most current DTC genetic tests evaluate … Read more
Multidisciplinary Surgical Team Approach Improves OS in Ovarian Cancer
November 1, 2023 9:00 amBy Hayden E. Klein
Patients with ovarian cancer saw a 70% improvement in overall survival (OS) 3 years after undergoing a multidisciplinary surgical approach compared with previous approaches to therapy, according to a study published in Annals of Surgical Oncology… Read more
Common Chemo Drugs May Not Work as We Thought
October 27, 2023 9:00 amClearity’s Perspective: New research demonstrates how paclitaxel (Taxol), a commonly used and effective drug for OC, works by disrupting cancer cell division. This research helps us to get a better understanding of the mechanism through which paclitaxel (Taxol) destroys cancer … Read more
Liquid Biopsy Shows Promise to Distinguish Benign Pelvic Masses from Tumorous Ones
October 11, 2023 9:00 amA new liquid biopsy test developed by researchers at USC Norris Comprehensive Cancer Center has shown promise to distinguish which pelvic masses are benign and which are tumorous, a development that could aid early diagnosis of high-grade serous ovarian carcinoma … Read more
Integrating Acupuncture Into a Cancer Treatment Plan
September 27, 2023 9:00 amKey Points:
- Acupuncture is a medical technique rooted in Chinese medicine that has beenused for millennia to improve health and well-being.
- Despite growing interest and increasing evidence for its effectiveness in reducing symptom burden, the use of acupuncture remains low
Experts urge study of psilocybin, other psychedelics for cancer-related distress
August 17, 2023 9:00 amThe prevalence of distress among women with late-stage gynecologic cancers calls for well-designed studies to assess the safety and efficacy of psychedelics for this patient population, according to authors of a published commentary.
Psychedelics — specifically psilocybin — have shown … Read more
Long DNA molecules reveal new scar types in HR-deficient cancers
August 16, 2023 9:00 amDNA can be damaged by toxins, radiation, or even normal cell division, but human cells must continually fix DNA breaks to survive. In cells that cannot repair DNA effectively, changes (mutations) can occur that lead to cancer.
Most cells rely … Read more
Using the immune system to stop ovarian cancer
August 16, 2023 9:00 amThe search for preventions and cures has turned inward—focusing on the immune system to stop ovarian cancer.
Professor Paul Hertzog’s research group at Hudson Institute of Medical Research has been working to expand on their discovery of a naturally occurring … Read more
Proteomics Pathway Diagnostic Helps Identify Platinum-Refractory Ovarian Cancers
August 9, 2023 9:00 amA new study describes a new diagnostic approach that could help identify the 15% of women with ovarian cancer whose tumors are intrinsically refractory to standard platinum-based therapies, the most common type of chemotherapy for the disease.
Most ovarian cancers … Read more
Protein Discovery Aids Ovarian Cancer Detection
July 7, 2023 9:00 amIn Science Advances, Nagoya University scientists publish their work discovering three membrane proteins associated with ovarian cancer. The research team are hopeful that their discovery could improve approaches for detecting and diagnosing the disease.
Reliable biomarkers lacking for ovarian
… Read more
Tumor Testing May Be Increasingly Useful in Ovarian Cancer
May 8, 2023 3:00 pmTesting tumors with next-generation sequencing in patients with ovarian cancer can provide teams insight into targetable mutations that may affect treatment decisions, although this approach is not the current standard of care for all patients, an expert said.
In an
Fred Hutch study highlights racial disparities in ovarian cancer risk for women
May 4, 2023 2:48 pmResearchers examined risks for Black and white women with endometriosis and fibroids to understand how common medical interventions for those conditions modified the outcomes
SEATTLE, WA — May 4, 2023 — A new Fred Hutchinson Cancer Center study in the
Preclinical Study Reveals New Target for Drug-Resistant Ovarian Cancer
April 18, 2023 1:04 pmThere are currently three antibody drug conjugates (ADC) targeting B7-H4 being tested in clinical trials: AZD8205 (NCT05123482), SGN-B7-H4V (NCT05194072) and XMT-1660 (NCT05377996). You can use Clearity’s clinical trial finder to find more information about these trials.
As part of the … Read more