Tweaking how CAR-T therapy kills tumors could stop a dangerous side effect, study finds

January 28, 2020 10:00 am

By Sharon Begley

As every trauma surgeon knows, there are messy bullet wounds and there are neat ones, and the former cause incomparably more trouble. If a team of scientists in China is right, the same principle may explain why … Read more

Use of intrauterine devices may decrease risk for ovarian cancer

January 24, 2020 10:00 am

About 14,000 women each year die of ovarian cancer, making it one of the deadliest gynecologic cancers.

Moreover, 80% of ovarian cancer diagnoses occur only after the disease has progressed to a late stage. The Ovarian Cancer Research Alliance estimated … Read more

“One-size-fits-all” cancer treatment could be on the horizon after scientists discover new immune cell by accident

January 24, 2020 10:00 am

By Kashmira Gander

Scientists have discovered a new cell in the immune system that can kill many types of cancer, which they hope could one day be used to create a “one size fits all” treatment for the disease.

In … Read more

PALB2 Linked to Increased Risk for Breast, Ovarian, and Pancreatic Cancer

January 8, 2020 10:00 am

By Christina Bennett, MS

Germline PALB2 pathogenic variants were associated with an increased risk for female breast cancer, male breast cancer, ovarian cancer, and pancreatic cancer, and these risks varied by age, according to data from an international study … Read more

Talc Powder Not Linked to Ovarian Cancer in Prospective Datasets

January 7, 2020 5:00 pm

By Ian Ingram

— With some 250,000 participants, study rules out all but smallest risk increases

New research on a quarter-million women from four U.S. cohorts found no significant association between ovarian cancer and the use of powder-based products in … Read more

Endometriosis Appears to Have No Effect on Ovarian Cancer Outcomes, But More Research Needed, Study Says

December 17, 2019 3:00 pm

By Marissa Wexler, MS

Endometriosis does not seem to significantly affect ovarian cancer prognosis and survival in patients of reproductive age, a small study suggests.

However, more research is needed to identify factors associated with the progression of endometriosis to … Read more

Small, Thin Metal Mesh Loaded With T Cells Shrinks Tumors in Ovarian Cancer Models

December 9, 2019 6:00 pm

What if a metal that’s already used to repair broken bones, straighten teeth and keep arteries from clogging could also be used to stop your cancer from spreading?

New findings published Dec. 9 in Nature Biomedical Engineering from scientists at … Read more

CA125 Test Detects Far More Ovarian Cancer Cases Than Thought

November 6, 2019 6:00 pm

By Liam Davenport

A blood test for detecting ovarian cancer is far more effective in the primary care setting than previously thought, say UK researchers, who suggest National Institute for Health and Care Excellence (NICE) guidelines will need to be … Read more

Genetically Definable Subgroups of Cancers Sensitive to Treatment

October 24, 2019 5:00 pm

Precision oncology aims to use genetic features of a patient’s tumor to tailor anti-cancer therapy. DNA mutations in a drug target have provided a number of therapeutic opportunities; however, there are many cancer types that do not have obvious targetable … Read more

‘Wild Idea’ Opens Possible New Frontier for Preventing Ovarian Cancer

October 9, 2019 3:00 pm

A laboratory study published in Clinical Cancer Research offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented.

The study is the first to show that the natural stiffening of the ovaries called fibrosis … Read more

UCSD Researchers Find FAK Protein Linked to Chemotherapy Resistance in Ovarian Cancer

September 12, 2019 5:00 pm

Although the number of women being diagnosed and dying of ovarian cancer is declining, recurrence, drug resistance, and mortality remains high for women with high-grade serous ovarian carcinoma, the most common form of epithelial ovarian cancer. 

A new study in Read more

Rare Ovarian Cancer Confirmed as Not Seeded from Elsewhere

September 6, 2019 5:15 pm

By Peter MacCallum

An international study led by Peter Mac has revealed the origin of mucinous ovarian cancer (MOC) confirming, unlike other types of ovarian cancer, this rare cancer is not seeded from elsewhere in the body.

The research provides … Read more

Researchers Develop Early Detection Test for Ovarian Cancer

August 23, 2019 5:00 pm

Researchers from Queen’s University Belfast have developed a test that may be able to detect ovarian cancer up to two years earlier than current approaches.

The researchers discovered that the presence of four proteins together, known as a biomarker panel, … Read more

Ovarian Cancer: Is this the Beginning of the End?

August 10, 2019 6:00 pm

By Michael J. Birrer, MD, PhD

There will be 22,530 new cases of ovarian cancer in the United States this year.

Although tumors often present at an advanced stage, it remains one of the most chemosensitive epithelial cancers, with a … Read more

BRCA Mutation, Preventive Surgery, and Osteoporosis

August 8, 2019 4:00 pm

By Kristen Monaco

Researchers advocate for increased hormone therapy for high-risk women.

Bone health suffered in women with a BRCA mutation who underwent preventive oophorectomy, Canadian researchers reported.

Premenopausal women with the BRCA1 or BRCA2 mutation experienced a significant decline … Read more

Germline BRCA2 Mutations Linked to Pediatric Lymphomas

August 2, 2019 5:00 pm

By Leah Lawrence

In addition to putting carriers at increased risk for breast and ovarian cancers, BRCA2 germline mutations carriers are also at increased risk for pediatric and adolescent non-Hodgkin lymphoma (NHL), according to data from the SJLIFE study.… Read more

Discovery of New “Don’t Eat Me Protein” Points the Way to Effective Cancer Therapy

August 1, 2019 4:00 pm

By Alexandru Micu

Stanford University (SU) researchers have found a new signaling molecule that cancer cells use to keep the immune system at bay.

Our bodies’ immune cells are, among other objectives, tasked with clearing out malfunctioning cells. In theory, … Read more

New Discovery Could Open Up PARP Inhibitors to More Cancer Patients

July 25, 2019 4:00 pm

By Amirah Al Idrus

PARP inhibitors have transformed treatment for breast and ovarian cancers, but their use has been limited to the small proportion of patients who have BRCA mutations. New research out of UT Southwestern Medical Center has uncovered … Read more

Targeting a Key Protein May Keep Ovarian Cancer Cells from Spreading

July 15, 2019 12:50 pm

By Zachary Sweger

Preventing a protein from doing its job may keep a certain type of ovarian cancer cell from growing and dividing uncontrollably in the lab, according to a new study from Penn State College of Medicine.

In … Read more

Ovarian Cancer and Bacteria in the Vagina: A New Study Found a Link, So We Asked the Experts What Women Need to Know

July 11, 2019 7:00 am

By Caroline Hopkins

The study found that younger women (under 50) with ovarian cancer had lower levels of “good bacteria” in their vaginas than women who were cancer-free. But the experts said we shouldn’t draw any conclusions about cancer risk Read more