Clearity Caregiver’s Week – Denise and Michelle’s Story

February 21, 2021 6:00 pm

Eleven years ago, my wife and I had the rug pulled out from under us. Michelle was diagnosed with ovarian cancer, and we were thrust into a new, alien world—Michelle as patient, and me as caregiver—a role I frankly wasn’t … Read more

How Biomarker Testing May Help Women Battling Ovarian Cancer

February 18, 2021 6:00 pm

Receiving a cancer diagnosis can be overwhelming. But the more you know about your specific situation, the better.

By

Every year, more than 21,000 women in the United States are diagnosed with ovarian cancer. In about half of

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Clearity Caregiver’s Week: Laurie and Jason’s Story

February 18, 2021 2:00 am

When diagnosed, there’s so much to deal with. After years of warning signs and my primary care doctor treating me for a myriad of medical issues, I presented with excruciating torso and belly pain, a distended stomach & difficulty breathing … Read more

Proton Therapy Induces Biologic Response to Attack Treatment-Resistant Cancers

February 17, 2021 4:00 pm

Mayo Clinic researchers have developed a novel proton therapy technique to more specifically target cancer cells that resist other forms of treatment. The technique is called LEAP, an acronym for “biologically enhanced particle therapy.” The findings are published today in … Read more

Improving Cancer Immunotherapy by Blocking Glucose Supply

February 17, 2021 11:00 am

All cells use sugar as a vital source of energy and building blocks. Unfortunately, that means even cancer cells use sugar. Researchers at Memorial Sloan Kettering (MSK) Cancer Center wondered what happens when tumor cells and immune cells battle for … Read more

Common Genetic Test Often Wrong When Identifying Rare Disease-Causing Variants Such as BRCA1 and BRCA2, Study Says

February 16, 2021 10:00 am

By Sandee LaMotte, CNN

A genetic test used to detect common traits many people share is not reliable in identifying rare disease-causing variations, such as those that can predict breast and ovarian cancer, a new study has found.

The SNP … Read more

Moffitt Researchers Discover Mechanism that Regulates Anti-Tumor Activity of Immune Cells

February 3, 2021 3:00 am

The study finally paves the way for the use of antibodies different from IgG as immunotherapeutic agents for at least tumors currently resistant to conventional immune checkpoint blockade.

The prognosis of ovarian cancer is poor, with an estimated five-year survival … Read more

Wee1 Inhibitor Gets Win in Tough-to-Treat Ovarian Cancer

January 25, 2021 5:00 pm

By Ian Ingram

Adding the Wee1 inhibitor adavosertib to gemcitabine reduced the risk of disease progression and death in women with recurrent, platinum-resistant or -refractory ovarian cancer, a randomized phase II trial showed.

For the primary endpoint of progression-free survival … Read more

Nulliparity, Not ART, Likely Raises Risk of Ovarian Cancer

January 19, 2021 5:00 pm

By Mark L. Fuerst

Women who receive ovarian stimulation for assisted reproductive technology (ART) procedures don’t have an increased risk of developing ovarian cancer when compared to subfertile women who don’t undergo ART, according to a new study.

The results … Read more

COVID-19 Vaccine & Patients with Cancer

January 15, 2021 6:00 pm

On December 17, 2020, the American Society of Clinical Oncology and Infectious Diseases Society of America held a “COVID-19 Vaccine & Patients with Cancer” webinar to discuss the importance of COVID-19 vaccination and to provide expert opinion on its use … Read more

Link Between Driver of Ovarian Cancer and Metabolism Opens Up New Therapeutic Strategies

January 11, 2021 3:00 pm

Loss of ARID1A causes increased glutamine metabolism, which can be blocked pharmacologically to target ARID1A-mutant tumors.

Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according … Read more

‘Virtual Biopsies’ Could Replace Tissue Biopsies in Future Thanks to Technique Developed by Cambridge Scientists

January 6, 2021 5:00 am

A new advanced computing technique using routine medical scans to enable doctors to take fewer, more accurate tumour biopsies, has been developed by cancer researchers at the University of Cambridge. This is an important step towards precision tissue sampling for

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Proper Staging of Early-Stage Ovarian Cancer Before Treatment Provides Critical Information for Potentially Improved Outcomes

January 5, 2021 6:00 am

A gynecologic oncology expert from the University of California, Davis reviewed early-stage ovarian cancer and the importance of knowing what options are available before, during and after treatment.

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Although patients diagnosed with early-stage ovarian cancer can … Read more

PARP Inhibitors Linked With Blood Cancer Risk

December 28, 2020 11:00 am

Incidence of MDS/AML under 1%, but further investigation warranted as indications broaden

By Leah Lawrence

Although rare, poly-ADP ribose polymerase (PARP) inhibitors were associated with an increased risk for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and occurred even … Read more

CURE Media Group Bolsters Strategic Alliance Partnership Program With 12 New Partners

December 18, 2020 1:00 pm

The Clearity Foundation is proud to announce its partnership with CURE Media Group, opening up many opportunities for us to reach more women and families who can directly benefit from our services. Specifically, having Clearity’s ovarian cancer experts participate in

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Oral Contraceptive Pills Protect Against Ovarian and Endometrial Cancer, Study Finds

December 18, 2020 11:00 am

A study has shown that the use of oral contraceptives gave women a much lower risk of developing both ovarian and endometrial cancer.

A study involving more than 250,000 women has shown that the use of oral contraceptives can protect … Read more

“Love, Loss and Remembering” – A Special Message From Our Executive Director, Hillary Theakston

December 12, 2020 3:00 pm

Dear Clearity Community,

We’re sharing a beautiful and important podcast from Kelly Corrigan with you today –“Love, Loss and Remembering” is now available on the Kelly Corrigan Wonders podcast. While this may not be the best time of year … Read more

Phase 1 Study of Novel Drug for Ovarian Cancer Shows Positive Results

December 5, 2020 6:00 pm

One patient had a complete response and the majority of patients achieved disease control at 12 weeks.

A phase 1 trial of an anti-folate receptor alpha (FolRα) human immunoglobulin G1 (IgG1) antibody for women with advanced ovarian cancer showed responses

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Elevated Stress Hormone Levels Could Reawaken Dormant Cancer Cells, Study Finds

December 2, 2020 5:00 pm

By Shraddha Chakradhar

The recurrence of cancer months or even years after successful treatment is an all too common phenomenon, and scientists have been chipping away at understanding how undetectable cells can once again unleash disease on the body — … Read more

SEngine Precision Medicine IDs Potential Ovarian Cancer Treatment Combos Using Organoid Approach

November 23, 2020 8:00 pm

By Caroline Hopkins

Using organoids that closely model certain features of ovarian tumors, researchers have identified and tested treatment combinations that may benefit patients, many of whom experience acquired or de novo resistance to PARP inhibitors.

In a study recently … Read more