Claudine Isaacs, MD, on the Limitations of At-Home Genetic Tests for Hereditary Breast/Ovarian Cancers

More than 95% of BRCA1 or BRCA1 pathogenic variants would have been missed by DTC testing, largest such study showed

November 8, 2023 9:00 am

By Mark Fuerst

Direct-to-consumer (DTC) genetic testing has limited use as a screening tool for identifying individuals at risk of hereditary breast or ovarian cancer, especially in those of non-Ashkenazi Jewish descent, researchers reported.

Most current DTC genetic tests evaluate … Read more

T-DXd Tied to Encouraging Survival in HER2-Expressing Gyn Cancers

November 7, 2023 9:00 am

RAF/MEK and FAK Inhibitor Combo Effective in Low-Grade Serous Ovarian Cancer

November 5, 2023 9:00 am

Clearity’s Perspective: The combination of avutometinib and defactinib has shown encouraging activity in Low-Grade Serous Ovarian Cancer. Updated results from the RAMP 201 trial suggest that the combination is active regardless of the number of prior therapies patients have received. Read more

Multidisciplinary Surgical Team Approach Improves OS in Ovarian Cancer

November 1, 2023 9:00 am

By Hayden E. Klein

Patients with ovarian cancer saw a 70% improvement in overall survival (OS) 3 years after undergoing a multidisciplinary surgical approach compared with previous approaches to therapy, according to a study published in Annals of Surgical OncologyRead more

Study Finds Shortcomings in Monitoring Caregivers’ Emotional Health

October 27, 2023 4:58 pm

By Sharon Reynolds

Clearity offers psychosocial support to caregivers through our Steps Through OC program. If you would like personal one-to-one assistance with the stress and challenges associated with caring for a loved one with an ovarian cancer diagnosis, our Read more

Common Chemo Drugs May Not Work as We Thought

October 27, 2023 9:00 am

Clearity’s Perspective: New research demonstrates how paclitaxel (Taxol), a commonly used and effective drug for OC, works by disrupting cancer cell division. This research helps us to get a better understanding of the mechanism through which paclitaxel (Taxol) destroys cancer Read more

Celebrating Life While Honoring Death: Q&A with our Oncology Chaplain, Michael Eselun

October 20, 2023 9:00 am

Michael Eselun, Clearity’s Oncology Chaplain, sat down with our Director of Education, Danielle Peterson, to discuss what occasions like the Jewish New Year Celebration, Rosh Hashanah, and Día de los Muertos can teach us about the role the contemplation of … Read more

Liquid Biopsy Shows Promise to Distinguish Benign Pelvic Masses from Tumorous Ones

October 11, 2023 9:00 am

A new liquid biopsy test developed by researchers at USC Norris Comprehensive Cancer Center has shown promise to distinguish which pelvic masses are benign and which are tumorous, a development that could aid early diagnosis of high-grade serous ovarian carcinoma … Read more

Ovarian Cancer: Best Practices for Managing PARP Inhibitor Side Effects

October 4, 2023 9:00 am

Oncologists treating ovarian cancer need to be proactive to prevent or reduce the likelihood of adverse effects associated with poly (ADP-ribose) polymerase (PARP) inhibitors, noted authors of a review in the ASCO Educational Book.

William Tew, MD, of Memorial Sloan … Read more

First Blood Test for Dozens of Hereditary Cancers Approved by FDA

October 2, 2023 9:00 am

The FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. The Invitae Common Hereditary Cancers Panel evaluates a blood sample to identify DNA variants in 47 genes associated with an elevated risk … Read more

Dr Rebecca Brooks Covers Ovarian Cancer Risk Factors, Preventive Measures

September 29, 2023 9:00 am

By Hayden E. Klein

For Ovarian Cancer Awareness Month in September, Rebecca Brooks, MD, talked to The American Journal of Managed Care® (AJMC®) about how genetics and family history play a large role in ovarian cancer … Read more

Integrating Acupuncture Into a Cancer Treatment Plan

September 27, 2023 9:00 am

Key Points:

  • Acupuncture is a medical technique rooted in Chinese medicine that has beenused for millennia to improve health and well-being.
  • Despite growing interest and increasing evidence for its effectiveness in reducing symptom burden, the use of acupuncture remains low
Read more

HIPEC Improves Long-Term Outcomes in Stage III Ovarian Cancer

September 25, 2023 9:00 am

By Andrea S. Blevins Primeau, PhD, MBA

Adding hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery improves long-term outcomes in patients with stage III epithelial ovarian cancer, according to updated trial results published in The Lancet Oncology.

These 10-year … Read more

Personalized cancer vaccine and adoptive T cell therapy benefits patients with advanced ovarian cancer: Study

September 21, 2023 9:00 am

By Andrea S. Blevins Primeau, PhD, MBA

A Ludwig Cancer Research study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development at the Lausanne Branch of the Ludwig Institute for Cancer Research … Read more

New Integrative Oncology Guidelines Provide Patients More Control Over Their Care

September 14, 2023 9:00 am

Clearity offers psychosocial support through our Steps Through OC program for patients, survivors and caregivers. If you would like personal one-to-one assistance with the stress and challenges associated with an ovarian cancer diagnosis, our team of OC Counselors can help Read more

Clinical trial gives women with gene mutation power over disease

September 8, 2023 9:00 am

Shared by Norma Rabago

When Juana Padron, a 40-year-old mother of four, chose to have a genetic test, going against her friends and family’s advice was the last thing on her mind.

Padron’s aunt died from breast cancer, and she … Read more

Phase 3 Trial of TTFields and Paclitaxel Misses OS End Point in Ovarian Cancer

August 28, 2023 9:00 am

The primary end point was not met in the phase 3 ENGOT-ov50 / GOG-3029 / INNOVATE-3 clinical trial of tumor treating fields therapy plus paclitaxel in patients with platinum-resistant ovarian cancer.

Patients with platinum-resistant ovarian cancer given tumor treating fields

Read more

Experts urge study of psilocybin, other psychedelics for cancer-related distress

August 17, 2023 9:00 am

The prevalence of distress among women with late-stage gynecologic cancers calls for well-designed studies to assess the safety and efficacy of psychedelics for this patient population, according to authors of a published commentary.

Psychedelics — specifically psilocybin — have shown … Read more

Long DNA molecules reveal new scar types in HR-deficient cancers

August 16, 2023 9:00 am

DNA can be damaged by toxins, radiation, or even normal cell division, but human cells must continually fix DNA breaks to survive. In cells that cannot repair DNA effectively, changes (mutations) can occur that lead to cancer.

Most cells rely … Read more

Using the immune system to stop ovarian cancer

August 16, 2023 9:00 am

The search for preventions and cures has turned inward—focusing on the immune system to stop ovarian cancer.

Professor Paul Hertzog’s research group at Hudson Institute of Medical Research has been working to expand on their discovery of a naturally occurring … Read more