Study Suggests QoL Assessments Do Not Support First-Line Combination Chemotherapy With Weekly Paclitaxel for Epithelial Ovarian Cancer

July 21, 2020 6:00 pm

By Susan Moench, PhD, PA-C

Results of quality of life (QoL) assessments from the randomized, phase 3 ICON8 study evaluating once-weekly vs thrice-weekly administration of paclitaxel in combination with carboplatin as first-line chemotherapy in patients with epithelial ovarian cancer do … Read more

Universal BRCA Testing Could Prevent Countless Cancer Deaths

July 17, 2020 1:00 pm

By Diana Swift

Population screening found to be cost-effective for higher income countries

Screening entire populations of women for mutations in breast and ovarian cancer susceptibility genes could prevent hundreds of thousands of cases in the U.S., and millions globally, … Read more

Ovarian Cancer Metastasis Study Identifies Important Protein with Potential as Diagnostic Tool and Treatment Option

July 16, 2020 3:00 pm

By Clayton Boldt, Ph.D

Advanced ovarian cancer most commonly metastasizes to the omentum, a layer of fatty tissue that wraps around and protects internal organs in the abdomen, but the reasons for this have not been well-understood. In a new … Read more

Surgical Removal of Fallopian Tubes to Prevent Ovarian Cancer Rapidly Rising, More Research Needed to Support Its Continued Use

July 13, 2020 6:00 pm

Ten percent of women who received a hysterectomy and salpingectomy, or removal of the fallopian tubes, during the study period had a family history of breast or ovarian cancer.

By Ryan McDonald

Despite limited data to support its use, the … Read more

Blood Test Detects Dozens of Cancer Types, Often Before Symptoms Emerge

July 13, 2020 5:00 pm

A novel blood test accurately detected more than 50 types of cancer with a specificity of 99.3%.

By Mark Leiser

A novel blood test accurately detected more than 50 types of cancer with a specificity of 99.3%, according to results … Read more

Study: The Immune Effects of Seclidemstat in Aggressive Ovarian Cancer Striking Young Women

July 13, 2020 3:00 pm

A drug known as SP-2577 could help enable the body’s own immune system to attack ovarian cancer, according to a study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.

Published today in the scientific … Read more

Certain Recurring Symptoms May Be Linked to Ovarian Cancer

July 13, 2020 2:00 pm

A recent data analysis found that most women diagnosed with ovarian cancer (92%) experienced abdominal and pelvic-related symptoms and visited a physician with this complaint anywhere from six to 70 months prior to diagnosis.

By Ryan McDonald

Data from a … Read more

New Cancer Vaccine Ready for Human Trials

July 10, 2020 6:00 pm

According to new research published in Clinical and Translational Immunology, a new cancer vaccine is ready for human trials following its success in preclinical studies.

By Alana Hippensteele

The vaccine was recently developed by a research team based at The … Read more

Pap Tests May Hold Biomarkers Ahead of Ovarian Cancer Diagnosis

July 10, 2020 4:00 pm

High-grade serous epithelial ovarian cancer may be detected earlier in the course of the disease by testing for TP53 clonal variants in DNA from Pap tests.

By Leah Lawrence

High-grade serous epithelial ovarian cancer may be detected earlier in the … Read more

WEE1 Kinase Inhibitor Improved PFS in TP53-Mutated Ovarian Cancer

July 8, 2020 5:00 am

Preclinical studies of adavosertib indicated that the drug increased sensitization of TP53-mutated cells to chemotherapy.

By Leah Lawrence

Adavosertib, a WEE1 kinase inhibitor, plus carboplatin and paclitaxel improved progression-free survival (PFS) in women with TP53-mutated, platinum-sensitive ovarian cancer compared … Read more

A White Paper on the Need for Consistent Terms for Testing in Precision Medicine

July 7, 2020 7:00 am

For years, The Clearity Foundation has emphasized the importance of tumor profiles/blueprints for informing decisions about treatment for ovarian cancer. Yet, genetic and tumor biomarker testing are not universally performed despite evidence that positive results in these tests could suggest … Read more

This MicroRNA Might Help Detect, Treat Ovarian Cancer

June 26, 2020 6:00 pm

In cell and mouse models, miR-181a showed promise as a biomarker for early stage ovarian cancer and may help make immunotherapy treatment more effective.

By Ian Demsky

A microRNA that is normally involved in immune cell differentiation helps to initiate

Read more

Neoadjuvant Chemotherapy Increases Immunogenicity of High-Grade Serous Ovarian Cancer

June 23, 2020 9:00 am

By Susan Moench, PhD, PA-C

High-grade serous ovarian cancer (HGSOC) is characterized by a high level of intrinsic heterogeneity in the tumor-immune microenvironment that is modified by chemotherapy, according to findings published in Nature Genetics.

HGSOC, a common and … Read more

Treatment with Lipophilic Statins Shows Lower Mortality Rate for Patients with Epithelial Ovarian Cancer

June 22, 2020 6:00 pm

A study presented at the AACR Virtual Annual Meeting II showed a significant decrease in mortality rate for patients with epithelial ovarian cancer when treated with lipophilic statins, supporting the further evaluation of statins to treat ovarian cancer in randomized Read more

Single-Cell Analysis of Ovarian Cancer Points to Potential Treatment Avenue

June 22, 2020 10:00 am

Inhibiting the JAK/STAT pathway could represent a potential treatment for high-grade serous ovarian cancer, according to a single-cell analysis.

Researchers led by the Broad Institute’s Aviv Regev used single-cell RNA sequencing (scRNA-seq) to analyze about 11,000 cells from ascites from … Read more

New Test Paves the Way for Tailored Treatment of Deadliest Form of Ovarian Cancer

June 18, 2020 4:00 pm

University of British Columbia (UBC) researchers have led an international team in developing a new test to better diagnose different types of ovarian cancer, a tool that could one day guide and improve treatment options for women diagnosed with the … Read more

‘We Have a Job to Do’: Cancer Patients and Their Doctors Carry on With Clinical Trials During Covid-19

June 17, 2020 5:00 pm

By Elizabeth Cooney

Cancer isn’t waiting for Covid-19 to go away. Neither is Karen Howley.

Diagnosed two years ago with advanced ovarian cancer, Howley started on a new experimental drug in mid-March, just as coronavirus case counts were soaring in … Read more

Berzosertib: Protein-Targeting Drug Used to Treat Cancer May Have Same Effect on Coronavirus

June 16, 2020 7:00 pm

Scientists have begun using berzosertib, a protein-targeting drug, as an accompaniment to chemotherapy for patients with ovarian cancer. The drug is currently in its second phase of trials with cancer patients and is showing promising results for how it … Read more

FDA Approves Pembrolizumab for TMB-High Tumors

June 16, 2020 3:00 am

The FDA has approved pembrolizumab (Keytruda) to treat adult and pediatric patients with unresectable or metastatic solid tumors that are tissue tumor mutational burden–high (≥10 mutations/megabase) and have progressed following prior therapy and who have no satisfactory alternative treatment options.Read more