Are We Closer to Screening Average-Risk Women for Ovarian Cancer?

Are We Closer to Screening Average-Risk Women for Ovarian Cancer?

A worldwide effort is under way to find new methods to screen women with no known risk factors for ovarian cancer.The disease is often aggressive and progresses quickly; only 40 percent of women who have it survive more than five years. Yet the diagnosis often takes women by surprise, as the cancer causes few if any symptoms when first developing. (Though screening guidelines already exist for women at increased risk for the disease due to a family history of the illness.)Early diagnosis is essential, as surgery and other currently available treatments are more effective when ovarian cancer is identified at an early stage, before it has spread beyond the pelvis. When the disease is caught early, Memorial Sloan Kettering’s specialized ovarian cancer surgery team can remove all cancerous tissue relatively easily, often saving a woman’s life and, in some cases, eliminating the need for chemotherapy or other treatments.

Through Research, Hope for Effective Screening Options

With the discovery several years ago that most cases of ovarian cancer originate at the end of the fallopian tubes, investigators are zeroing in on new biomarkers — indictors that disease is present — and also learning more about known biomarkers secreted in high concentrations near this part of the body. Other studies are determining if biomarkers can be found in the bloodstream.

At MSK, researchers are exploring the value of “washing” the uterus with fluid and analyzing the fluid for biomarkers. This test is currently in a technology development phase (not in clinical trials), as researchers collect more samples from patients. Dr. Levine foresees its use one day in an office setting.

Another promising avenue of investigation utilizes nanotechnology to detect tiny bits of tumor proteins that may indicate ovarian cancer. Researchers are developing approaches to make this tactic reliably sensitive enough to spot ominous changes in both the bloodstream and fluid from uterine washings.

“Surgery to remove the ovaries and fallopian tubes has proven to be a lifesaver for women at high risk,” Dr. Levine adds. Researchers at MSK and elsewhere are planning studies to explore the removal of the fallopian tubes in average-risk women who’ve completed childbearing and are having pelvic surgery for unrelated reasons to see if there’s a protective effect.

To read this study by Memorial Sloan Kettering Cancer Center on The Clearity Portal, click here.

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