A Phase III, Multicenter, Randomized, Study of Atezolizumab Versus Placebo Administered in Combination With Paclitaxel, Carboplatin, and Bevacizumab to Patients With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Trial ID # NCT03038100; IMagyn050
Phase III
Drug Class Immunotherapy: Checkpoint Inhibitors/PD-L1
Drug Name Atezolizumab
Alternate Drug Names Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A , MPDL3280A, RG7446
Drugs in Trial Atezolizumab, Bevacizumab, Carboplatin, Paclitaxel
Eligible Participant

Newly diagnosed stage III/IV ovarian cancer (neo-adjuvant or adjuvant and maintenance)

Patients Enrolled


Therapy Setting


Study Design

Double Blind, Randomized


PFS, OS, evaluated per RECIST




CarboPt+Pac+Bev+Aze w/ Bev+Aze maint vs CarboPt+Pac+Bev+Placebo w/ Bev+Placebo maint:

PFS: 19.5 vs 18.4 months, HR: 0.92 (0.79–1.07)
OS: 50.5 vs 46.6 months, HR: 0.92 (0.78-1.09)

PD-L1+ patients: patients with ≥ 1% of tumor-infiltrating immune cells expressing PD-L1:
PFS: 20.8 vs 18.5 months, HR: 0.80 (0.65–0.99)
OS: NR. vs 49.2 months, HR: 0.83 (0.66-1.09, p=0.13) 

Clinically Significant Adverse Events

CarboPt+Pac+Bev+Aze w/ Bev+Ate maint vs CarboPt+Pac+Bev+Placebo w/ Bev+Placebo maint:
Serious AE:
Grade 3-4 AE:


Atezolizumab does not significantly improve PFS or OS in the ITT or PD-L1+ population. The combination is generally well tolerated with manageable AEs; neither BRCA1/2 MUT nor HRD+ was associated with greater clinical benefit from adding atezolizumab


Moore KN et al. Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39). J Clin Oncol (2021) 39(17):1842-1855

Pignata S et al. Overall survival and patient-reported outcome results from the placebo-controlled randomized phase III IMagyn050/GOG 3015/ENGOT-OV39 trial of atezolizumab for newly diagnosed stage III/IV ovarian cancer. Gynecol Oncol (2023) 177:20-31

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