‘Personalized’ Ovarian CA Vaccine May Prolong Survival

April 16, 2018 9:42 pm

A novel cancer vaccine made from autologous whole-tumor and dendritic cells significantly improved survival in women with recurrent advanced epithelial ovarian cancer (EOC), given alone or in combination with standard immunomodulatory therapy, researchers found.

An international pilot study in 25 … Read more

New Immunotherapy Shows Promise Against Ovarian Cancer

April 10, 2018 8:57 pm

Ovarian cancer can be tough to beat, particularly if it returns after initial treatment, but new research offers a glimmer of hope.

One study found that a new targeted “immunotherapy” to treat ovarian cancer that has come back looked promising … Read more

Participation In Clinical Trials May Eliminate Ovarian Cancer Survival Disparities

April 4, 2018 5:22 pm

Improving the diversity of enrollment in clinical trials may improve health disparities among women with ovarian cancer, according to study results presented at the Society of Gynecologic Oncology Annual Meeting on Women’s Cancer.

“Our study is evidence that no one … Read more

SGO 2018: Immunotherapy/PARP Inhibitor Combination Produces Remissions in Ovarian Cancer

April 2, 2018 5:19 pm

A combination of the immunotherapy pembrolizumab (Keytruda) and the DNA repair–blocking agent niraparib (Zejula) can be significantly more effective than either drug alone in women with hard-to-treat ovarian cancer, a phase I/II clinical trial led by Dana-Farber Cancer Institute researchers … Read more

SGO 2018: A Vaccine Shows Promise Against Ovarian Cancer

March 26, 2018 9:11 pm

A vaccine derived from a patient’s tumor cells, which enhances T-cell targeting of cancer cells, has shown promise against ovarian cancer.

This outcome of a phase 1 clinical trial was reported at the Society of Gynecologic Oncology’s 2018 Annual Meeting … Read more

Vulnerable Populations Lack Sufficient Clinical Trial Information

March 21, 2018 2:30 pm

Despite showing an interest in clinical trials and biobanking, underserved populations appear to be unclear on how to learn about them, while community physicians reported lacking appropriate information to give them, according to data to be presented at the American … Read more

Why Many Patients Join Phase 1 Clinical Trials

March 7, 2018 6:12 am

“Fighting my cancer as much as possible” is why many patients participate in early stage clinical trials, according to research presented at the TAT (Targeted Anticancer Therapies) International Congress 2018 in Paris, France.

“The importance of early stage trials is … Read more

Clinical Trials Offer Promising New Treatments for Ovarian Cancer

February 5, 2018 9:10 pm

By: Deborah Zajchowski, PhD – Scientific Director, The Clearity Foundation

In the past three years, new hope has come to many women with ovarian cancer because of four new drugs that were approved for the treatment of this disease. These … Read more

Women with Ovarian Cancer Who May Benefit from Maintenance Treatment

January 15, 2018 6:18 pm

Myriad Genetics and AstraZeneca have expanded their collaboration to conduct a study to identify women with advanced ovarian cancer who may benefit from maintenance treatment with Lynparza (olaparib) and Avastin (bevacizumab).

Myriad’s myChoice HRD Plus is a test for BRCA1 … Read more

Combinations May Be The Future Of Immunotherapy In Ovarian Cancer

January 12, 2018 10:27 pm

To date, trials testing the use of immunotherapy in the treatment of ovarian cancer yielded disappointing results. However, researchers are not giving up. Instead, they’re investigating to see if immunotherapy drugs – such as PD1 and PDL-1 inhibitors – can … Read more

Foundation For Women’s Cancer Fights To End Clinical Trial Crisis

January 10, 2018 6:36 pm

When Wendy Ericsson learned she had uterine cancer in December 2012 she went looking for information, but didn’t find much out there about her disease.

Through her doctor, she was directed to the Foundation for Women’s Cancer (FWC).

“There’s a … Read more

The Crisis in Gynecological Cancer Research

September 18, 2017 7:39 pm

By: Susan Gubar

As an ovarian cancer patient whose life is being extended by a clinical trial, I was delighted to learn this summer that research on gynecological cancers is undergoing an unusually productive period. But I’m dismayed that at … Read more

Cancer Patients Struggle to Understand Clinical Trials

September 10, 2017 5:40 pm

Cancer patients struggle to understand what is involved in a clinical trial, even when they have participated in them. In a survey of 1090 adult cancer patients, more than half did not understand the concepts of clinical equipoise or randomization.… Read more

A Cancer Conundrum: Too Many Drug Trials, Too Few Patients

August 16, 2017 3:25 pm

With the arrival of two revolutionary treatment strategies, immunotherapy and personalized medicine, cancer researchers have found new hope — and a problem that is perhaps unprecedented in medical research.

There are too many experimental cancer drugs in too many clinical … Read more

Clinical Trials Are the Way Forward for Ovarian Cancer

July 13, 2017 6:44 pm

For women with ovarian cancer, the message is clear: participating in clinical trials, even early-phase ones, offers the best hope for better treatments, but efforts are urgently needed at every level to ensure that more of these research opportunities are … Read more

CT Technology Shows How Blood Flow Can Predict Ovarian Cancer Treatment

July 7, 2017 4:59 pm

Technology developed at Western University and Lawson Health Research Institute can provide a new window into whether or not patients are responding to treatment for advanced ovarian cancer. A multi-centre clinical trial has demonstrated that CT Perfusion, which measures blood … Read more

ImmunoGen Drug Moving Ahead In Single-Agent, Combination Trials

May 19, 2017 7:13 pm

Latest results from a mid-stage trial of ImmunoGen Inc’s experimental antibody-drug conjugate show that it shrinks or stabilizes tumors in nearly half of advanced ovarian cancer patients with at least medium levels of a key biomarker whose disease has become Read more

Recruitment Begins for World’s First Ovarian Cancer Vaccine Trial

April 21, 2017 6:16 pm

UConn Health is beginning to recruit patients for the world’s first personalized genomics-driven ovarian cancer vaccine clinical trial. The goal: to prevent an often deadly relapse of the disease in women diagnosed at advanced stages.

The pioneering injectable vaccine OncoImmunome … Read more

New Clinical Trial Combines Two Methods to Defeat Ovarian Cancer

January 12, 2017 3:31 am

Fewer than half of women diagnosed with ovarian cancer live for five years or more. Sarah Adams, MD, a cancer doctor at the UNM Comprehensive Cancer Center, hopes a new therapy that delivers a one-two punch to cancer cells will … Read more

Precision Medicine Yields Better Outcomes for Clinical Trial Patients

June 2, 2016 6:21 pm

A meta-analysis of 346 phase I clinical trials involving more than 13,000 patients found that patients whose treatment was selected based on the molecular characteristics of their tumor had significantly better outcomes. The study was featured in a press briefing … Read more