| Trial ID # | NCT03038100; IMagyn050 |
| Phase | III |
| Drug Class | Immunotherapy: Checkpoint Inhibitors/PD-L1 |
| Drug Name | Atezolizumab |
| Alternate Drug Names | Tecentriq, Anti-PD-L1 Monoclonal Antibody MPDL3280A , MPDL3280A, RG7446 |
| Drugs in Trial | Atezolizumab, Carboplatin, Paclitaxel, Bevacizumab |
| Eligible Participant | Newly diagnosed stage III/IV ovarian cancer (neo-adjuvant or adjuvant and maintenance) |
| Patients Enrolled | 1301 |
| Therapy Setting | First-line |
| Study Design | Double Blind, Randomized |
| Endpoints | PFS, evaluated per RECIST |
| Biomarkers | PD-L1+ |
| Efficacy | CarboPt+Tax+Bev+Aze w/ Bev+Aze maint vs CarboPt+Tax+Bev+Placebo w/ Bev+Placebo maint: PFS: 19.5 vs 18.4 months, HR: 0.92 (0.79–1.07) PD-L1+ patients: patients with ≥ 1% of tumor-infiltrating immune cells expressing PD-L1: |
| Clinically Significant Adverse Events | CarboPt+Tax+Bev+Aze w/ Bev+Aze maint vs CarboPt+Tax+Bev+Placebo w/ Bev+Placebo maint: |
| Conclusion | Atezolizumab does not significantly improve PFS in the ITT or PD-L1+ population. The combination is generally well tolerated with manageable AEs; neither BRCA1/2 MUT nor HRD+ was associated with greater clinical benefit from adding atezolizumab |
| Reference | Moore KN et al. Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39). J Clin Oncol (2021) 39(17):1842-1855 |