Topo II Inhibitors

Topo II Inhibitor Resistance Marker
Marker Name Biological Role Evidence References
PGP (MDR1, ABCB1) P-Glycoprotein; multi-drug resistance protein 1 ATP-binding cassette transporter and drug efflux pump for anthracyclines High expression associated with poor responses and outcomes to doxorubicin therapy in ovarian cancer TopoII Inhibitor Resistance: PGP References