Topo I Inhibitors

Topo I Inhibitors	Mechanism of Action
Topotecan, irinotecan, camptothecin	Inhibits DNA synthesis and RNA transcription by blocking activity of topoisomerase I

Green squares, sensitivity markers. Red squares, resistance markers

Drugs and Biomarkers

• Drug Response Biomarkers Summary
• Platinum
  • MOA and Biomarkers
  • Sensitivity Markers
  • Resistance Markers
  • References
• Taxanes
  • MOA and Biomarkers
  • Sensitivity Markers
  • Resistance Markers
  • References
• Nucleoside Analogs
  • MOA and Biomarkers
  • Gemcitabine Sensitivity Markers
  • Gemcitabine Resistance Markers
  • References
• Topo I Inhibitors
  • MOA
  • Sensitivity Markers
  • References
• Topo II Inhibitors
  • MOA and Biomarkers
  • Sensitivity Markers
  • Resistance Markers
  • References
• Fluoropyrimidines and Anti-folates
  • MOA and Biomarkers
  • 5-FU Resistance Marker
  • Pemetrexed Resistance Marker
  • Capecitabine Sensitivity Markers
  • Capecitabine Resistance Marker
  • References
• Methods