Topo I Inhibitors
| Topo I Inhibitor Sensitivity Markers | ||||
|---|---|---|---|---|
| Marker | Name | Biological Role | Evidence | References |
| Top1 | Topoisomerase 1 | Enzyme unwinds supercoiled DNA to permit strand separation required for DNA replication and transcription | High Top1 mRNA and protein levels correlated with good response to irinotecan-based therapy in ovarian and colorectal cancer patients | TopoI Inhibitor Sensitivity: Top1 References |
