Taxane Sensitivity Marker

Taxane Sensitivity Marker
Marker	Name	Biological Role	Evidence	References
BRCA1	Breast cancer 1 (Breast and ovarian cancer susceptibility gene)	DNA repair (Homologous recombination-- double strand break repair)	High mRNA expression correlated with good response and outcomes following taxane-based treatment in ovarian and NSCLC	Taxane Sensitivity: BRCA1 References
SPARC	Secreted protein, acidic, cysteine-rich (osteonectin)	matrix-associated protein that modulates cell shape, cell proliferation, extracellular matrix production	High protein expression correlated with good response in head & neck cancers	Nab-paclitaxel Sensitivity: SPARC Reference

Marker

Name

Biological Role

Evidence

References

BRCA1

Breast cancer 1 (Breast and ovarian cancer susceptibility gene)

DNA repair (Homologous recombination-- double strand break repair)

High mRNA expression correlated with good response and outcomes following taxane-based treatment in ovarian and NSCLC

SPARC

Secreted protein, acidic, cysteine-rich (osteonectin)

matrix-associated protein that modulates cell shape, cell proliferation, extracellular matrix production

High protein expression correlated with good response in head & neck cancers