| Gemcitabine Resistance Markers
|
| Marker | Name | Biological Role | Evidence | References |
| RRM1 | ribonucleotide reductase, regulatory subunit M1
| Enzyme synthesizes deoxyribonuceosides from ribonucleoside precursors
| High protein levels associated with poor response and outcome in pancreatic, biliary, and NSCLC patients after gemcitabine-based therapy | Gemcitabine Resistance:
RRM1 References |
| RRM2
| ribonucleotide reductase, regulatory subunit M2
| Enzyme synthesizes deoxyribonuceosides from ribonucleoside precursors
| High mRNA expression correlated with poor outcome following gemcitabine treatment in pancreatic, NSCL, and ovarian cancer
| Gemcitabine Resistance:
RRM2 References
|
